Shima K, Tanaka A, Ejiri N, Maezawa H
Bull Tokyo Med Dent Univ. 1985 Dec;32(4):169-77.
To determine the predictive risk factors of the severity of the coronary artery disease, the serum levels of lipoprotein cholesterol and apolipoprotein were measured in 103 patients undergoing coronary angiography examination for suspected myocardial ischemia. The extent and severity of the coronary artery disease (CAD) were assessed by assigning scores to each lesion. Twenty-six female patients (59 +/- 8 yrs.) showed a stronger relationship of apo B and apo A-I/B to the coronary scores than the 77 male patients (57 +/- 8 yrs.). The male patients were divided into four groups based on the coronary scores: H-CAD (range: over 11 points), M-CAD (5-10 points), L-CAD (1-4 points) and N-CAD (0 point). The atherogenic risk factors other than the abnormalities in lipid metabolism (obesity index, fasting plasma glucose, smoking and blood pressure) were well matched in the four groups. T.C., LDL-C., HDL-C., HDL2-C., apo B, apo A-I/B ratio and apo A-II/B ratio significantly differed in the H-CAD and N-CAD groups. These results indicate that T.C., LDL-C., HDL-C., HDL2-C., apo B, apo A-I/B ratio and apo A-II/B ratio are predictive risk factors of the coronary heart disease. Furthermore, apo B and apo A-I/B ratio significantly differed in the H-CAD and L-CAD groups. These results suggest that apo B and apo A-I/B ratio may be good discriminators of the severity of the coronary heart disease.
为了确定冠状动脉疾病严重程度的预测风险因素，对103例因疑似心肌缺血接受冠状动脉造影检查的患者测定了脂蛋白胆固醇和载脂蛋白的血清水平。通过对每个病变进行评分来评估冠状动脉疾病（CAD）的范围和严重程度。26例女性患者（59±8岁）显示，载脂蛋白B和载脂蛋白A-I/B与冠状动脉评分的关系比77例男性患者（57±8岁）更强。根据冠状动脉评分将男性患者分为四组：高CAD组（范围：超过11分）、中CAD组（5 - 10分）、低CAD组（1 - 4分）和无CAD组（0分）。四组中除脂质代谢异常（肥胖指数、空腹血糖、吸烟和血压）外的动脉粥样硬化风险因素匹配良好。总胆固醇（T.C.）、低密度脂蛋白胆固醇（LDL-C.）、高密度脂蛋白胆固醇（HDL-C.）、高密度脂蛋白2胆固醇（HDL2-C.）、载脂蛋白B、载脂蛋白A-I/B比值和载脂蛋白A-II/B比值在高CAD组和无CAD组中有显著差异。这些结果表明，总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、高密度脂蛋白2胆固醇、载脂蛋白B、载脂蛋白A-I/B比值和载脂蛋白A-II/B比值是冠心病的预测风险因素。此外，载脂蛋白B和载脂蛋白A-I/B比值在高CAD组和低CAD组中有显著差异。这些结果表明，载脂蛋白B和载脂蛋白A-I/B比值可能是冠心病严重程度的良好鉴别指标。
