Bergunde L, Steudte-Schmiedgen S, Karl M, Jaramillo I, Gao W, von Soest T, Garthus-Niegel S
Institute and Policlinic of Occupational and Social Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Department of Psychotherapy and Psychosomatic Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Sci Rep. 2024 Apr 24;14(1):9459. doi: 10.1038/s41598-024-59818-6.
Analysis of endocannabinoids (ECs) and N-acylethanolamines (NAEs) in hair is assumed to retrospectively assess long-term EC/NAE concentrations. To inform their use, this study investigated stability of EC/NAE hair concentrations in mothers, fathers, and their children across the perinatal period as well as associations between family members. In a prospective cohort study, EC (AEA, 1-AG/2-AG) and NAE (SEA, PEA, OEA) levels were quantified in hair samples taken four times in mothers (n = 336) and their partners (n = 225) from pregnancy to two years postpartum and in offspring (n = 319) from shortly after birth to two years postpartum. Across the perinatal period, maternal and paternal hair ECs/NAEs showed poor multiple-test consistency (16-36%) and variable relative stability, as well as inconsistent absolute stability for mothers. Regarding children, hair ECs/NAEs evidenced poor multiple-test consistency (4-19%), no absolute stability, and either no or variable relative stability. Hair ECs/NAEs showed small to medium significant associations across the perinatal period within couples and parent-child dyads. Findings suggest hair ECs/NAEs during the perinatal period possess variable stability in adults, albeit more stability in fathers than mothers in this time. This highlights the need to further investigate factors associated with changes in hair ECs/NAEs across time. The first two years of life may be a dynamic phase for the endocannabinoid system in children, potentially characterized by complex within-family correspondence that requires further systematic investigation.
分析头发中的内源性大麻素（ECs）和N-酰基乙醇胺（NAEs）被认为可以回顾性评估长期的EC/NAE浓度。为了为其应用提供信息，本研究调查了围产期母亲、父亲及其子女头发中EC/NAE浓度的稳定性以及家庭成员之间的关联。在一项前瞻性队列研究中，对母亲（n = 336）及其伴侣（n = 225）从怀孕到产后两年期间四次采集的头发样本以及后代（n = 319）从出生后不久到产后两年期间采集的头发样本中的EC（AEA、1-AG/2-AG）和NAE（SEA、PEA、OEA）水平进行了定量分析。在整个围产期，母亲和父亲头发中的ECs/NAEs显示出较差的多次测试一致性（16 - 36%）和可变的相对稳定性，母亲的绝对稳定性也不一致。对于儿童，头发中的ECs/NAEs显示出较差的多次测试一致性（4 - 19%），没有绝对稳定性，相对稳定性要么没有要么可变。在围产期，夫妻和亲子二元组中头发ECs/NAEs显示出小到中等程度的显著关联。研究结果表明，围产期成人头发中的ECs/NAEs具有可变的稳定性，尽管在此期间父亲的稳定性高于母亲。这突出了需要进一步研究与头发ECs/NAEs随时间变化相关的因素。生命的头两年可能是儿童内源性大麻素系统的一个动态阶段，其特征可能是复杂的家庭内部对应关系，需要进一步系统研究。
