评估结外侵犯程度对局部晚期口腔癌结局的影响。
Evaluating the impact of the degree of extranodal extension on outcomes in locally advanced oral cavity cancer.
机构信息
Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA.
出版信息
Head Neck. 2024 Sep;46(9):2340-2347. doi: 10.1002/hed.27782. Epub 2024 Apr 25.
BACKGROUND
Evaluate whether extranodal extension (ENE) extent impacts outcomes in patients with oral cavity squamous cell carcinoma (OCSCC).
METHODS
From an institutional database, patients with OCSCC and pathologic ENE who received adjuvant treatment were included. Surgical slides were reviewed to confirm ENE extent. Multivariable Cox regression was used to relate patient/treatment characteristics with disease-free survival (DFS) and overall survival (OS). ENE was analyzed as both a dichotomous and continuous variable.
RESULTS
A total of 113 patients were identified. Between major (>2 mm) versus minor ENE (≤2 mm), there was no significant difference in DFS (HR 1.18, 95%CI 0.72-1.92, p = 0.51) or OS (HR 1.17, 95%CI 0.70-1.96, p = 0.55). There was no significant association between ENE as a continuous variable and DFS (HR 0.97 per mm, 95%CI 0.87-1.4, p = 0.96) or OS (HR 0.96 per mm, 95%CI 0.83-1.11, p = 0.58).
CONCLUSION
No significant relationship was seen between ENE extent and DFS or OS in individuals with OCSCC.
背景
评估口腔鳞状细胞癌（OCSCC）患者的结外扩展（ENE）程度是否对结局有影响。
方法
从机构数据库中纳入接受辅助治疗的 OCSCC 且有病理 ENE 的患者。通过复查手术切片来确认 ENE 程度。多变量 Cox 回归用于分析患者/治疗特征与无病生存（DFS）和总生存（OS）的关系。ENE 分析采用二分类和连续变量两种方法。
结果
共确定了 113 名患者。在主要（>2mm）与次要 ENE（≤2mm）之间，DFS（HR 1.18，95%CI 0.72-1.92，p=0.51）或 OS（HR 1.17，95%CI 0.70-1.96，p=0.55）无显著差异。ENE 作为连续变量与 DFS（HR 每毫米 0.97，95%CI 0.87-1.4，p=0.96）或 OS（HR 每毫米 0.96，95%CI 0.83-1.11，p=0.58）之间也无显著关联。
结论
在 OCSCC 患者中，ENE 程度与 DFS 或 OS 之间未见显著关系。
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