Li Ji, Wang Shiyu, Li Xiao-Dong, Han Yang
Department of Dermatology, Central Hospital Affiliated To ShenYang Medical College, 5 Nanqi West Road, 110024, Shenyang, Liaoning, China.
J Int Med Res. 2024 Apr;52(4):3000605241247702. doi: 10.1177/03000605241247702.
Generalized pustular psoriasis (GPP) is characterized by painful and occasionally disfiguring cutaneous manifestations with sepsis-like systemic symptoms, and is a rare severe variant of psoriasis. Currently, there is no standard treatment for GPP. Here, we report a case of a female patient with ankylosing spondylitis (AS) and mild scalp psoriasis, who developed GPP and alopecia following three courses of adalimumab therapy. The patient's condition gradually improved following cessation of adalimumab and treatment with secukinumab and acitretin. After eight weeks of treatment, the patient achieved almost complete clearance of her psoriasis, her alopecia improved, and her AS was relieved. Therefore, we believe that a combination of secukinumab with acitretin may be a rational approach for the treatment of severe GPP.
泛发性脓疱型银屑病（GPP）的特征是伴有类似败血症的全身症状的疼痛性且偶尔会毁容的皮肤表现，是银屑病的一种罕见严重变体。目前，GPP尚无标准治疗方法。在此，我们报告一例患有强直性脊柱炎（AS）和轻度头皮银屑病的女性患者，在接受三个疗程的阿达木单抗治疗后发生了GPP和脱发。停用阿达木单抗并使用司库奇尤单抗和阿维A治疗后，患者的病情逐渐改善。经过八周的治疗，患者的银屑病几乎完全清除，脱发有所改善，AS也得到缓解。因此，我们认为司库奇尤单抗与阿维A联合使用可能是治疗重度GPP的合理方法。
