NEIL3：一种参与链间 DNA 交联修复的独特 DNA 糖基化酶。
NEIL3: A unique DNA glycosylase involved in interstrand DNA crosslink repair.
机构信息
Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA.
Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA; Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA.
出版信息
DNA Repair (Amst). 2024 Jul;139:103680. doi: 10.1016/j.dnarep.2024.103680. Epub 2024 Apr 21.
Abstract
Endonuclease VIII-like 3 (NEIL3) is a versatile DNA glycosylase that repairs a diverse array of chemical modifications to DNA. Unlike other glycosylases, NEIL3 has a preference for lesions within single-strand DNA and at single/double-strand DNA junctions. Beyond its canonical role in base excision repair of oxidized DNA, NEIL3 initiates replication-dependent interstrand DNA crosslink repair as an alternative to the Fanconi Anemia pathway. This review outlines our current understanding of NEIL3's biological functions, role in disease, and three-dimensional structure as it pertains to substrate specificity and catalytic mechanism.
摘要
内切核酸酶 VIII 样 3（NEIL3）是一种多功能 DNA 糖苷酶，可修复 DNA 上的多种化学修饰。与其他糖苷酶不同，NEIL3 偏爱单链 DNA 中的损伤以及单/双链 DNA 连接处的损伤。除了在氧化 DNA 的碱基切除修复中的典型作用外，NEIL3 还作为范可尼贫血途径的替代物，启动复制依赖性链间 DNA 交联修复。本文综述了我们目前对内切核酸酶 VIII 样 3 的生物学功能、在疾病中的作用以及三维结构的理解，这些内容与底物特异性和催化机制有关。
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