Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA; Howard Hughes Medical Institute, Boston, MA, USA.
Trends Immunol. 2024 May;45(5):327-328. doi: 10.1016/j.it.2024.04.005. Epub 2024 Apr 24.
Lawrence et al. report that fetal cortical boundaries are susceptible to morphogenetic stress that regulates a microglia state resembling postnatal, axon-tract associated microglia (ATM). This state performs a newfound function at these boundaries by preventing the formation of cavitary lesions, mediated in part by Spp1-regulated phagocytosis of fibronectin 1.
劳伦斯等人报告称，胎儿皮质边界易受形态发生应激的影响，这种应激调节一种类似于出生后、与轴突束相关的小胶质细胞（ATM）的小胶质细胞状态。这种状态在这些边界处发挥了新的功能，部分通过 Spp1 调节的纤维连接蛋白 1 的吞噬作用来防止腔隙性病变的形成。
