Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto, 862-0973, Japan.
Kumamoto Industrial Research Institute, 3-11-38 Higashi-machi, Higashi-ku, Kumamoto, 862-0901, Japan.
J Antibiot (Tokyo). 2024 Jul;77(7):471-474. doi: 10.1038/s41429-024-00727-1. Epub 2024 Apr 25.
Benastatin K (1), a new chlorinated benastatin derivative, was isolated from the culture broth of the actinomycete Streptomyces sp. HGTA384. The structure of 1 was determined on the basis of spectroscopic analysis, including 1D and 2D NMR, as well as HRESI-MS, UV and IR, and comparison with data reported in the literature. Compound 1 and benastatins A and B exhibited inhibitory activity against Micrococcus luteus (MIC 7.8, 31.3, and 3.9 μM, respectively), and IgE-mediated β-hexosaminidase release in RBL-2H3 cells with IC values of 42, 79, and 19 μM, respectively.
从放线菌 Streptomyces sp. HGTA384 的发酵液中分离得到一种新的氯苯酞斯汀衍生物贝那他汀 K（1）。根据光谱分析，包括 1D 和 2D NMR 以及 HRESI-MS、UV 和 IR，并与文献报道的数据进行比较，确定了 1 的结构。化合物 1 和贝那他汀 A 和 B 对微球菌（MIC 分别为 7.8、31.3 和 3.9 μM）和 RBL-2H3 细胞中 IgE 介导的β-己糖胺酶释放具有抑制活性，IC 值分别为 42、79 和 19 μM。
