从链霉菌 HS-NF-1178 中分离得到的两种新型 lankacidin 相关代谢产物。
Two new lankacidin-related metabolites from Streptomyces sp. HS-NF-1178.
机构信息
Life Science and Biotechnology Research Center, School of Life Science, Northeast Agricultural University, Harbin, 150030, China.
Department of New Drug Screening, Zhejiang Hisun Pharmaceutical Co., Ltd, Taizhou, 318000, China.
出版信息
J Antibiot (Tokyo). 2018 Mar;71(3):397-401. doi: 10.1038/s41429-017-0004-0. Epub 2018 Jan 18.
Two new lankacidin-related metabolites, 2,18-seco-lankacidinol A (1), 2,18-seco-lankacidinol B (2) and a known compound, lankacidinol (3), were isolated from the fermentation broth of Streptomyces sp. HS-NF-1178. Their structures were determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as ESI-MS and comparison with data from the literature. These two new compounds, especially compound 1, exhibited potent antitumor activity.
从链霉菌 HS-NF-1178 的发酵液中分离得到了两个新的郎卡菌素相关代谢产物，2,18-去甲郎卡菌素 A（1）、2,18-去甲郎卡菌素 B（2）和一种已知化合物郎卡菌素（3）。基于光谱分析，包括 1D 和 2D NMR 技术以及 ESI-MS 以及与文献数据的比较，确定了它们的结构。这两个新化合物，特别是化合物 1，表现出很强的抗肿瘤活性。
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