Bettendorf U
Zentralbl Gynakol. 1979;101(11):689-97.
Radiotherapy of cervix carcinoma may cause radiation-borne reactive cell changes to epithelial cells of the vagina and portio which are sizeable but harmless. However, postradiation dysplasia with damage to the DNA and RNA is a genuine dysplasia and may be a precancerous condition. It is cytologically characterised by impairment of the nucleocytoplasmatic ratio as well as by hyperchromia and heterochromia of nuclei. Statistically secured correlation with recurrent carcinomas was established only for severe types with aneuploid DNA in the nuclei.
子宫颈癌放疗可能会使阴道和宫颈上皮细胞发生放射性反应性细胞改变，这些改变较为明显但无害。然而，放疗后伴有DNA和RNA损伤的发育异常是一种真正的发育异常，可能是癌前病变。其细胞学特征为核质比受损以及细胞核的深染和异染色质。仅在细胞核中具有非整倍体DNA的严重类型中，才在统计学上确定了与复发性癌的相关性。
