Kabodmehri Roya, Ghanami Gashti Nasrin, Zahiri Sorouri Ziba, Sharami Seyedeh Hajar, Milani Forozan, Hasanpour Marziyeh, Eslami-Kenarsari Habib, Rafiei Sorouri Zahra
Department of Obstetrics and Gynecology, Reproductive Health Research Center, Al-Zahra Hospital, School of Medicine Guilan University of Medical Sciences Rasht Iran.
Mehr Fertility Research Center Guilan University of Medical Sciences Rasht Iran.
Health Sci Rep. 2024 Apr 10;7(4):e2015. doi: 10.1002/hsr2.2015. eCollection 2024 Apr.
This study aimed to examine maternal serum concentration of β-human chorionic gonadotropin (β-hCG) on Day 16 after embryo transfer and risk of miscarriage, pre-eclampsia, and intrauterine growth restriction (IUGR).
In this study, we evaluated 125 pregnancies following in vitro fertilization (IVF). β-hCG concentrations were measured on the morning of Day 16 after embryo transfer. Baseline characteristics of the study participants were also recorded.
Concentrations of β-hCG on Day 16 after embryo transfer were inversely associated with the higher risk of miscarriage ( < 0.001), but did not with pre-eclampsia and IUGR ( > 0.05). Spearman's correlation coefficient showed a reverse and significant association between β-hCG and higher risk of miscarriage ( = 0.531 and < 0.001). There was a significant association between frozen embryo transfer and the risk of IUGR and pre-eclampsia ( = 0.005 and = 0.023, respectively).
Maternal serum concentrations of β-hCG on Day 16 after IVF/embryo transfer were associated with the higher risk of miscarriage, but not pre-eclampsia and IUGR.
本研究旨在检测胚胎移植后第16天母体血清β-人绒毛膜促性腺激素（β-hCG）浓度以及流产、子痫前期和胎儿生长受限（IUGR）的风险。
在本研究中，我们评估了125例体外受精（IVF）后的妊娠情况。在胚胎移植后第16天早晨测量β-hCG浓度。还记录了研究参与者的基线特征。
胚胎移植后第16天的β-hCG浓度与流产风险较高呈负相关（<0.001），但与子痫前期和胎儿生长受限无关（>0.05）。Spearman相关系数显示β-hCG与流产风险较高呈反向且显著相关（=0.531，<0.001）。冷冻胚胎移植与胎儿生长受限和子痫前期风险之间存在显著关联（分别为=0.005和=0.023）。
IVF/胚胎移植后第16天母体血清β-hCG浓度与流产风险较高相关，但与子痫前期和胎儿生长受限无关。
