Department of Research & Development, Taiji Clinic, Taipei, Taiwan.
Department of Research & Development, Taiji Clinic, Taipei, Taiwan.
Taiwan J Obstet Gynecol. 2021 Sep;60(5):831-835. doi: 10.1016/j.tjog.2021.07.009.
To compare the prevalence of congenital fetal anomalies or intrauterine fetal growth restriction (IUGR) diagnosed prenatally between two in-vitro fertilization (IVF) methods-fresh embryo transfer (ET) and frozen embryo transfer (FET).
We retrospectively reviewed medical records of patients that had conceived via IVF, and had a fetal anatomical scan performed at Taiji Clinic between 2015 and 2019. The prevalence of fetal anomalies or IUGR between both IVF methods were compared. Prevalence of congenital anomalies or IUGR by maternal age and embryo transfer type were compared by means of Chi-square analysis. Using multivariate logistic regression, we investigated factors that might be associated with higher rates of fetal anomalies or IUGR, such as parity and number of embryos transferred.
A total of 2441 cases were selected (ET: n = 627 and FET: n = 1814). There was non-significant difference in the prevalence of fetal anomalies or IUGR between ET and FET groups (6.4% vs. 5.5%, p = 0.39). However, among women younger than 34 years of age, prevalence of fetal anomalies or IUGR was significantly higher in ET group (4.6% vs. 9.9%, p = 0.03).
Our findings suggest an age-specific effect of IVF method on the rate of fetal anomalies or IUGR and may provide useful information for physicians and infertile couples to optimize their IVF treatment plans and improve birth outcomes.
比较新鲜胚胎移植（ET）和冷冻胚胎移植（FET）两种体外受精（IVF）方法诊断的胎儿先天畸形或宫内胎儿生长受限（IUGR）的发生率。
我们回顾性分析了 2015 年至 2019 年在太极诊所通过 IVF 受孕并进行胎儿解剖扫描的患者的病历。比较了两种 IVF 方法的胎儿畸形或 IUGR 发生率。通过卡方分析比较了母体年龄和胚胎移植类型对先天畸形或 IUGR 的发生率的影响。采用多变量逻辑回归分析了与胎儿畸形或 IUGR 发生率较高相关的因素，如产次和移植胚胎数。
共选择了 2441 例（ET：n=627，FET：n=1814）。ET 组和 FET 组胎儿先天畸形或 IUGR 的发生率无显著差异（6.4%vs.5.5%，p=0.39）。然而，在年龄小于 34 岁的女性中，ET 组胎儿先天畸形或 IUGR 的发生率明显较高（4.6%vs.9.9%，p=0.03）。
我们的研究结果表明，IVF 方法对胎儿先天畸形或 IUGR 发生率有年龄特异性影响，可为医生和不孕夫妇提供有用信息，以优化其 IVF 治疗计划，改善出生结局。
