Mohtasham Nooshin, Zarepoor Marzieh, Shooshtari Zahra, Hesari Kiana Kamyab, Mohajertehran Farnaz
Dental Research Center Faculty of Dentistry of Mashhad University of Medical Sciences Mashhad Iran.
Department of Oral and Maxillofacial Pathology School of Dentistry, Mashhad University of Medical Sciences Mashhad Iran.
Health Sci Rep. 2024 Apr 24;7(4):e1977. doi: 10.1002/hsr2.1977. eCollection 2024 Apr.
Oral squamous cell carcinoma is the most prevalent malignancy in the oral cavity, with a significant mortality rate. In oral squamous cell carcinoma patients, the survival rate could decrease because of delayed diagnosis. Thus, prevention, early diagnosis, and appropriate treatment can effectively increase the survival rate in patients. In this systematic review, we discussed the role of different genes in oral squamous cell carcinoma metastasis. Herein, we aimed to summarize clinical results, regarding the potential genes that promote oral squamous cell carcinoma metastasis.
This systematic review was carried out under the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. An electronic search for all relevant articles published in English between January 2018 and April 2022 was performed using Scopus, PubMed, and Google Scholar search engines. All original studies published in English were included, and we excluded studies that were in a non-English language.
A total of 4682 articles were found, of which 14 were relevant and detected significant genes in oral squamous cell carcinoma progression. These findings investigated the overexpression of interferon-induced proteins with tetratricopeptide repeats 1 and 3 (IFIT1, IFT3), high-mobility group A2 (HMGA2), transformed growth factor-beta-induced, lectin galactoside-binding soluble 3 binding protein (LGALS3BP), bromodomain containing 4, COP9 signaling complex 6, heterogeneous nuclear ribonucleoproteins A2B1 (HNRNPA2B1), 5'-3' exoribonuclease 2 (XRN2), cystatin-A (CSTA), fibroblast growth factors 8 (FGF8), forkhead box P3, cadherin-3, also known as P-cadherin and Wnt family member 5A, ubiquitin-specific-processing protease 7, and retinoic acid receptor responder protein 2 genes lead to promote metastasis in oral squamous cell carcinoma. Overexpression of some genes (IFIT1, 3, LGALS3BP, HMGA2, HNRNPA2B1, XRN2, CSTA, and FGF8) was proven to be correlated with poor survival rates in oral squamous cell carcinoma patients.
Studies suggest that metastatic genes indicate a poor prognosis for oral squamous cell carcinoma patients. Detecting these metastatic genes in oral squamous cell carcinoma patients may be of predictive value and can also facilitate assessing oral squamous cell carcinoma development and its response to treatment.
口腔鳞状细胞癌是口腔中最常见的恶性肿瘤，死亡率较高。在口腔鳞状细胞癌患者中，由于诊断延迟，生存率可能会降低。因此，预防、早期诊断和适当治疗可有效提高患者的生存率。在本系统评价中，我们探讨了不同基因在口腔鳞状细胞癌转移中的作用。在此，我们旨在总结关于促进口腔鳞状细胞癌转移的潜在基因的临床结果。
本系统评价按照系统评价和Meta分析的首选报告项目指南进行。使用Scopus、PubMed和谷歌学术搜索引擎对2018年1月至2022年4月期间以英文发表的所有相关文章进行电子检索。纳入所有以英文发表的原始研究，排除非英文语言的研究。
共检索到4682篇文章，其中14篇相关文章检测到口腔鳞状细胞癌进展中的重要基因。这些研究发现，四肽重复序列1和3的干扰素诱导蛋白（IFIT1、IFT3）、高迁移率族蛋白A2（HMGA2）、转化生长因子-β诱导的半乳糖凝集素结合可溶性3结合蛋白（LGALS3BP）、含溴结构域4、COP9信号复合体亚基6、不均一核核糖核蛋白A2B1（HNRNPA2B1）、5'-3'外切核糖核酸酶2（XRN2）、胱抑素A（CSTA）、成纤维细胞生长因子8（FGF8）、叉头框蛋白P3、钙黏蛋白3（又称P-钙黏蛋白）、Wnt家族成员5A、泛素特异性加工蛋白酶7和视黄酸受体应答蛋白2基因的过表达会促进口腔鳞状细胞癌的转移。一些基因（IFIT1、3、LGALS3BP、HMGA2、HNRNPA2B1、XRN2、CSTA和FGF8）的过表达被证明与口腔鳞状细胞癌患者的低生存率相关。
研究表明，转移基因提示口腔鳞状细胞癌患者预后不良。在口腔鳞状细胞癌患者中检测这些转移基因可能具有预测价值，也有助于评估口腔鳞状细胞癌的发展及其对治疗的反应。
