Khan Wafa, Haragannavar Vanishri C, Rao Roopa S, Prasad Kavitha, Sowmya Samudrala Venkatesiah, Augustine Dominic, Patil Shankargouda
Department of Oral Pathology & Microbiology, Faculty of Dental Sciences, M.S. Ramaiah University of Applied Sciences, MSR Nagar, Bengaluru, 560054, Karnataka, India.
Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, M.S. Ramaiah University of Applied Sciences, MSR Nagar, Bengaluru, 560054, Karnataka, India.
Clin Oral Investig. 2022 Jan;26(1):259-273. doi: 10.1007/s00784-021-03996-4. Epub 2021 Jul 3.
Oral cancer progression is a multi-step process in which adhesion molecules play a pivotal role in the development of recurrent, invasive, and distant metastasis. The aim of this study was to adopt prognostic biomarkers to assess the lymph node metastasis of OSCC that will facilitate in deciding the treatment modality by the surgeons.
The objectives of the study were to assess the biological behaviour of OSCC by correlating the expression levels of P-Cadherin and WNT5A immunohistochemically.
A total of 60 selected OSCCs cases (lymph node metastasis n = 30, non-metastatic n = 30) and 10 normal healthy controls were quantitatively and qualitatively analysed by immunohistochemistry for P-Cadherin and WNT5A. A survival analysis was also performed.
The expression levels of P-Cadherin and WNT5A in OSCC groups were statistically significant between metastatic and non-metastatic groups (p < 0.001). P-Cadherin and WNT5A expression in metastatic (lymph node metastasis) and non-metastatic cases showed a significant correlation coefficient of 0.753 at (p < 0.01). The present study also found that the aberrant expression (high) of P-Cadherin was associated with diminished survival of patients with metastatic OSCC.
The present study demonstrated the aberrant expression of P-Cadherin and WNT5A could serve as important prognosticator in OSCC.
P-Cadherin and WNT5A could be used as significant predictors of disease outcome.
口腔癌进展是一个多步骤过程，其中黏附分子在复发、侵袭和远处转移的发展中起关键作用。本研究的目的是采用预后生物标志物来评估口腔鳞状细胞癌（OSCC）的淋巴结转移情况，这将有助于外科医生决定治疗方式。
本研究的目的是通过免疫组织化学方法关联P-钙黏蛋白和WNT5A的表达水平，以评估OSCC的生物学行为。
通过免疫组织化学对60例选定的OSCC病例（淋巴结转移n = 30，非转移n = 30）和10例正常健康对照进行P-钙黏蛋白和WNT5A的定量和定性分析。还进行了生存分析。
OSCC组中P-钙黏蛋白和WNT5A的表达水平在转移组和非转移组之间具有统计学意义（p < 0.001）。转移（淋巴结转移）和非转移病例中P-钙黏蛋白和WNT5A的表达显示出显著的相关系数0.753（p < 0.01）。本研究还发现，P-钙黏蛋白的异常表达（高表达）与转移性OSCC患者的生存期缩短有关。
本研究表明，P-钙黏蛋白和WNT5A的异常表达可作为OSCC的重要预后指标。
P-钙黏蛋白和WNT5A可作为疾病预后的重要预测指标。
