Mulvey M, Woodruff D S
Biochem Genet. 1985 Dec;23(11-12):877-89. doi: 10.1007/BF00499935.
The snail, Biomphalaria glabrata, is a major intermediate host of the human blood fluke, Schistosoma mansoni, in the Americas. The inheritance and linkage relationships of a gene enabling adult snails to resist infection by a Puerto Rican strain of the parasite were analyzed using two laboratory stocks that differed in susceptibility, pigmentation, and five electrophoretically detectable enzyme markers. Segregation ratios in second-generation intraspecific hybrids between susceptible (M-stock) and resistant (10-R2-stock) snails indicate that the susceptibility gene is not linked to the enzyme (ACON-1, ACP, EST-2, PEP-2, PGD) or pigmentation loci studied. These seven loci assort independently of one another. Observed rates of infection among F1 and F2 progeny are consistent with Richards' finding that adult susceptibility to the PR-1 strain of S. mansoni is controlled by a single locus with resistance dominant. No association between allozymes of acid phosphatase and snail susceptibility to PR-1 was seen in the snail-parasite combinations studied.
光滑双脐螺是美洲地区人体血吸虫曼氏血吸虫的主要中间宿主。利用在易感性、色素沉着以及五个可通过电泳检测的酶标记方面存在差异的两个实验室种群，对一个使成年螺能够抵抗波多黎各寄生虫株感染的基因的遗传和连锁关系进行了分析。易感（M种群）和抗性（10-R2种群）螺之间第二代种内杂交的分离比表明，易感性基因与所研究的酶（乌头酸酶-1、酸性磷酸酶、酯酶-2、肽酶-2、6-磷酸葡萄糖脱氢酶）或色素沉着基因座没有连锁关系。这七个基因座彼此独立分配。在F1和F2后代中观察到的感染率与理查兹的发现一致，即成年螺对曼氏血吸虫PR-1株的易感性由一个单基因座控制，抗性为显性。在所研究的螺-寄生虫组合中，未发现酸性磷酸酶的别构酶与螺对PR-1的易感性之间存在关联。
