Suppr超能文献

单剂量灌胃给药后恩诺沙星在驴血浆、尿液和粪便中的药代动力学研究。

Pharmacokinetics of Enrofloxacin in Plasma, Urine, and Feces of Donkey () after a Single Intragastric Administration.

作者信息

Yang Bowen, Liu Shijie, Cheng Jie, Qu Honglei, Guo Yanxin, Ji Chuanliang, Wang Yantao, Zhao Shancang, Huang Shimeng, Zhao Lihong, Ma Qiugang

机构信息

State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.

National Engineering Research Center for Gelatin-Based Traditional Chinese Medicine, Dong-E-E-Jiao Co., Ltd., Liaocheng 252201, China.

出版信息

Antibiotics (Basel). 2024 Apr 12;13(4):355. doi: 10.3390/antibiotics13040355.

Abstract

Enrofloxacin is a broad-spectrum antimicrobial agent, but the study of its pharmacokinetics/pharmacodynamics (PKs/PDs) in donkeys is rarely reported. The present study aimed to investigate the pharmacokinetics of enrofloxacin administered intragastrically, and to study the pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin in plasma, urine, and feces, and the PK/PD parameters were investigated to provide a rationale for enrofloxacin treatment in donkeys. A total of five healthy donkeys were selected for intragastric administration of 7.5 mg·kg BW of enrofloxacin by gavage, and blood, urine, and fecal samples were collected. The results showed that the elimination half-life of plasma enrofloxacin was 11.40 ± 6.40 h, T was 0.55 ± 0.12 h, C was 2.46 ± 0.14 mg·L, AUC was 10.30 ± 3.37 mg·L·h, and mean residence time (MRT) was 7.88 ± 1.26 h. The T of plasma ciprofloxacin was 0.52 ± 0.08 h, C was 0.14 ± 0.03 mg·L, and AUC was 0.24 ± 0.16 mg·L·h. Urinary C was 38.18 ± 8.56 mg·L for enrofloxacin and 15.94 ± 4.15 mg·L for ciprofloxacin. The total enrofloxacin and ciprofloxacin recovered amount in urine was 7.09 ± 2.55% of the dose for 144 h after dosing. The total enrofloxacin and ciprofloxacin recovered amount in feces was 25.73 ± 10.34% of the dose for 144 h after dosing. PK/PD parameters were also examined in this study, based on published MICs. In conclusion, 7.5 mg/kg BW of enrofloxacin administered intragastrically to donkeys was rapidly absorbed, widely distributed, and slowly eliminated in their bodies, and was predicted to be effective against bacteria with MICs < 0.25 mg·L.

摘要

恩诺沙星是一种广谱抗菌剂,但关于其在驴体内的药代动力学/药效学(PKs/PDs)研究鲜有报道。本研究旨在研究经胃内给予恩诺沙星后的药代动力学,以及恩诺沙星及其代谢产物环丙沙星在血浆、尿液和粪便中的药代动力学,并研究PK/PD参数,为驴的恩诺沙星治疗提供理论依据。总共选择了5头健康的驴,通过灌胃给予7.5mg·kg体重的恩诺沙星,并采集血液、尿液和粪便样本。结果显示,血浆恩诺沙星的消除半衰期为11.40±6.40小时,达峰时间(T)为0.55±0.12小时,峰浓度(C)为2.46±0.14mg·L,药时曲线下面积(AUC)为10.30±3.37mg·L·h,平均驻留时间(MRT)为7.88±1.26小时。血浆环丙沙星的达峰时间为0.52±0.08小时,峰浓度为0.14±0.03mg·L,药时曲线下面积为0.24±0.16mg·L·h。恩诺沙星的尿液峰浓度为38.18±8.56mg·L,环丙沙星为15.94±4.15mg·L。给药后144小时,尿液中恩诺沙星和环丙沙星的总回收量为给药剂量的7.09±2.55%。给药后144小时,粪便中恩诺沙星和环丙沙星的总回收量为给药剂量的25.73±10.34%。本研究还根据已发表的最低抑菌浓度(MICs)检测了PK/PD参数。总之,给驴经胃内给予7.5mg/kg体重的恩诺沙星后,其在体内吸收迅速、分布广泛且消除缓慢,预计对MICs<0.25mg·L的细菌有效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ec9/11047589/4908b2168044/antibiotics-13-00355-g001.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验