Xu Mohan, Sun Qian, Wang Xiaoqing, Gao Hu, Liu Zhipeng
College of Materials Science and Engineering, College of Science, Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, People's Republic of China.
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, People's Republic of China.
Org Lett. 2024 May 10;26(18):3750-3755. doi: 10.1021/acs.orglett.4c00842. Epub 2024 Apr 26.
We report a series of ethenylene-bridged D-π-A BODIPY-xanthene hybrid dyes with precisely regulated absorption bands ranging from the far-red to the near-infrared region (NIR, 700-1000 nm) through rational molecular design. These dyes have excellent photoacoustic properties, and their biocompatibility can be significantly improved by facilely introducing water-soluble groups. In vivo two-channel multiplexed photoacoustic imaging demonstrated their high-resolution imaging capabilities, making them promising candidates for future NIR bioimaging applications.
我们报道了一系列通过合理的分子设计，具有精确调控吸收带的乙烯撑桥联D-π-A硼二吡咯-呫吨杂化染料，其吸收带范围从远红光到近红外区域（NIR，700-1000nm）。这些染料具有优异的光声性能，并且通过简单地引入水溶性基团，其生物相容性可以得到显著改善。体内双通道多路复用光声成像证明了它们的高分辨率成像能力，使其成为未来近红外生物成像应用的有前途的候选者。
