Koiter T R, Pols-Valkhof N, Zürcher A F, Schuiling G A
Acta Endocrinol (Copenh). 1979 Sep;92(1):28-45. doi: 10.1530/acta.0.0920028.
The LH-secretory response (LH-S.R.), caused by (standard) infusion of LH-RH, was estimated throughout pseudopregnancy (PSP) as well as on dioestrus - 1 and - 2 of the 4-day oestrous cycle. The LH-S.R. was judged according to 3 parameters: (1) mean maximal plasma LH concentration ("height", expressed in ng LH-RP-1/ml plasma), (2) mean area under the curve (AUC, expressed in "area units"), and (3) a composite, dimensionless, parameter: RQ ("response quotient"), defined as height/AUC. This latter parameter informs on the shape of the curve. The LH-S.R.'s on day 1 of PSP and dioestrus-1 were both relatively low (about 350 ng LH-RP-1/ml plasma) and characterized by the same RQ about 12). On days 2, 5, 7 and 9 of PSP the LH-S.R.'s were essentially the same and appeard to have characteristics of the LH-S.R.'s of both PSP-1 and dioestrus-1 (RQ) and dioestrus-2 (height; about 1000 ng LH-RP-1/ml plasma). From day 10 on the LH-S.R.'s became increasingly higher (PSP 11: about 1900 ng LH-RP-1/ml plasma; PSP 12: about 3300 ng LH-RP-1/ml plasma) and steeper (RQ equals about 22). At the end of PSP the spontaneous LH-surges were measured. These appeared to be very high if compared to those which are generated in 4-day cyclic rats (about 5800 ng LH-RP-1/ml plasma). The results indicate that a period of PSP is not simply an ovulatory cycle of which the dioestrous phase is extended by about a week and it is suggested that "active" corpora lutea secrete, next to progesterone, substances which play a key role in the regulation of the secretion of LH in the course of PSP.
在整个假孕（PSP）期间以及4天发情周期的间情期-1和-2，评估了由（标准）输注促黄体生成素释放激素（LH-RH）引起的促黄体生成素分泌反应（LH-S.R.）。根据3个参数判断LH-S.R.：（1）平均最大血浆促黄体生成素浓度（“高度”，以每毫升血浆中促黄体生成素RP-1的纳克数表示），（2）曲线下平均面积（AUC，以“面积单位”表示），以及（3）一个复合的无量纲参数：反应商（RQ），定义为高度/AUC。后一个参数反映了曲线的形状。PSP第1天和间情期-1的LH-S.R.均相对较低（约350纳克促黄体生成素RP-1/毫升血浆），且具有相同约为12的反应商。在PSP的第2、5、7和9天，LH-S.R.基本相同，似乎具有PSP-1和间情期-1（反应商）以及间情期-2（高度；约1000纳克促黄体生成素RP-1/毫升血浆）的LH-S.R.的特征。从第10天起，LH-S.R.变得越来越高（PSP 11：约1900纳克促黄体生成素RP-1/毫升血浆；PSP 12：约3300纳克促黄体生成素RP-1/毫升血浆）且更陡峭（反应商约为22）。在PSP末期测量了自发性促黄体生成素高峰。与4天周期大鼠产生的高峰相比，这些高峰似乎非常高（约5800纳克促黄体生成素RP-1/毫升血浆）。结果表明，PSP期并非简单地是一个排卵周期，其间情期延长约一周，并且提示“活跃”的黄体除了分泌孕酮外，还分泌在PSP过程中对促黄体生成素分泌调节起关键作用的物质。
