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A型肉毒毒素在痉挛中的作用：基于文献计量分析的研究趋势。

The Role of Botulinum Toxin Type-A in Spasticity: Research Trends from a Bibliometric Analysis.

机构信息

Spasticity and Movement Disorders "ReSTaRt", Unit Physical Medicine and Rehabilitation Section, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.

Department of Medical and Surgical Specialties and Dentistry, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.

出版信息

Toxins (Basel). 2024 Apr 9;16(4):184. doi: 10.3390/toxins16040184.

DOI:10.3390/toxins16040184
PMID:38668609
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11053519/
Abstract

Botulinum toxin type-A (BoNT-A) has emerged as a key therapeutic agent for the management of spasticity. This paper presents a comprehensive bibliometric and visual analysis of research concerning BoNT-A treatment of spasticity to elucidate current trends and future directions in this research area. A search was conducted in the Web of Science database for articles focused on the use of BoNT-A in spasticity published between 2000 and 2022. We extracted various metrics, including counts of publications and contributions from different countries, institutions, authors, and journals. Analytical methods in CiteSpace were employed for the examination of co-citations, collaborations, and the co-occurrence of keywords. Our search yielded 1489 publications. Analysis revealed a consistent annual increase in research output. The United States, United Kingdom, and Italy were the leading contributors. The top institution in this research was Assistance Publique Hopitaux, Paris. The journal containing the highest number of relevant publications was . Key frequently occurring keywords were 'stroke', 'cerebral palsy', 'adult spasticity', and 'upper extremity'. This study identified 12 clusters of keywords and 15 clusters of co-cited references, indicating the main focus areas and emerging themes in this field. This study comprehensively analyzed and summarized trends in BoNT-A research in the field of spasticity over the past 22 years.

摘要

肉毒毒素 A 型（BoNT-A）已成为治疗痉挛的重要治疗药物。本文对 BoNT-A 治疗痉挛的研究进行了全面的文献计量学和可视化分析，以阐明该研究领域的当前趋势和未来方向。在 Web of Science 数据库中对 2000 年至 2022 年间发表的关于 BoNT-A 在痉挛中应用的文章进行了搜索。我们提取了各种指标，包括出版物数量和来自不同国家、机构、作者和期刊的贡献。CiteSpace 中的分析方法用于检查共引、合作和关键词的共现。我们的搜索产生了 1489 篇出版物。分析显示，研究产出呈持续逐年增长。美国、英国和意大利是主要贡献者。该研究的顶级机构是巴黎公立医院集团。包含相关出版物数量最多的期刊是 。经常出现的关键词是“stroke”、“cerebral palsy”、“adult spasticity”和“upper extremity”。本研究确定了 12 个关键词聚类和 15 个共引文献聚类，表明了该领域的主要焦点和新兴主题。本研究全面分析和总结了过去 22 年来 BoNT-A 在痉挛领域的研究趋势。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eca/11053519/fe10810023a5/toxins-16-00184-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eca/11053519/6c6c54ad7185/toxins-16-00184-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eca/11053519/ecabbfc4272a/toxins-16-00184-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9eca/11053519/cc1ae9086861/toxins-16-00184-g010.jpg
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