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21 月龄女童 L1-L2 脊椎骨椎间盘炎的早期诊断与经验性治疗成功:病例报告。

Early Diagnosis and Successful Empirical Treatment of L1-L2 Spondylodiscitis in a 21-Month-Old Girl: A Case Report.

机构信息

Department of Pediatrics, Bahrain Defense Force Hospital, Riffa, Bahrain.

Department of Pediatric Neurology, Bahrain Defense Force Hospital, Riffa, Bahrain.

出版信息

Am J Case Rep. 2024 Apr 26;25:e943010. doi: 10.12659/AJCR.943010.

Abstract

BACKGROUND Infantile spondylodiscitis is a rare condition with a varied clinical presentation. Microbial infection may not always be identified, but early diagnosis and management are required to prevent long-term and irreversible complications, including spinal deformities and vertebral instability. CASE REPORT This report is of a 21-month-old girl with a 3-week history of difficulty in walking and constipation due to L1-L2 spondylodiscitis following a gluteal skin burn. The family had sought medical advice multiple times, but results of all investigations were unremarkable. Her initial spine X-ray was negative but her spine magnetic resonance imaging (MRI) showed a picture suggestive of spondylodiscitis, which then responded to empiric treatment with broad-spectrum antibiotics. The patient showed complete resolution of clinical symptoms and her bowel habits came back to normal after 6 months of complete antibiotics treatment. Her repeat spine MRI showed a significant improvement of her spondylodiscitis. CONCLUSIONS This report has highlighted the importance of rapid diagnosis and management of infantile spondylodiscitis and the challenging approach to treatment when no infectious organism can be identified, as well as the early initiation of antibiotics therapy when appropriate in pediatric patients to avoid serious neurological complications associated with spondylodiscitis. Thus, it is essential to assess children with refusal to walk, gait problems, or back discomfort, especially when they are associated with high inflammatory markers.

摘要

背景

婴儿期脊柱骨髓炎是一种临床表现多样的罕见疾病。微生物感染并非总是能被确定,但需要早期诊断和治疗,以预防长期和不可逆转的并发症,包括脊柱畸形和椎体不稳定。

病例报告

本报告介绍了一例 21 个月大的女孩,因臀侧皮肤烧伤导致 L1-L2 脊柱骨髓炎,出现行走困难和便秘,病史 3 周。家属多次求医,但所有检查结果均无异常。最初的脊柱 X 线片未见异常,但脊柱磁共振成像(MRI)显示符合骨髓炎的影像学表现,随后经验性使用广谱抗生素治疗有效。经过 6 个月的完全抗生素治疗,患者的临床症状完全缓解,排便习惯恢复正常。她的重复脊柱 MRI 显示骨髓炎明显改善。

结论

本报告强调了快速诊断和治疗婴儿脊柱骨髓炎的重要性,以及在无法确定感染病原体时的治疗挑战性,以及在适当情况下尽早开始抗生素治疗,以避免与骨髓炎相关的严重神经并发症。因此,对于拒绝行走、步态异常或背部不适的儿童,特别是当他们伴有高炎症标志物时,评估是至关重要的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3c6/11060496/32043973f3ad/amjcaserep-25-e943010-g001.jpg

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