Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China.
Ecotoxicol Environ Saf. 2024 Jun 1;277:116339. doi: 10.1016/j.ecoenv.2024.116339. Epub 2024 Apr 25.
Children's exposures to environmental antibiotics are a major public health concern. However, limited data are available on the effects of environmental antibiotic exposures on childhood obesity. Our study aimed to explore this relationship. We conducted a cross-sectional case-control study nested in a population-based survey of primary school students, including 1855 obese and 1875 random selected control children. A total of 10 antibiotics in urine samples were measured by liquid chromatography-tandem mass spectrometry. Multivariable survey logistic regression was used to assess the associations between environmental antibiotics exposures and childhood obesity. After adjusting for potential confounders, increased odds of obesity were observed in children exposed to tetracycline (OR = 1.31, 95% CI: 1.09-1.57) and sulfamonomethoxine (OR = 1.43, 95% CI: 1-2.05). Comparing none (<LODs), low-, middle-, and high-exposure groups, the low- sulfamonomethoxine exposure was associated with an increased odds of obesity (OR = 1.91, 95% CI: 1.05-3.47). Higher odds of obesity were associated with middle-level exposures to tetracycline (OR = 1.96, 95% CI: 1.05-3.66), doxycycline (OR = 1.56, 95% CI: 1-2.46), and lincomycin (OR = 1.35, 95% CI: 1.05-1.74). However, no significant association was found in any high-level antibiotic exposure groups. The significant associations were mainly observed in boys. The associations between environmental antibiotics exposures and childhood obesity are non-linear. Low- to middle-level exposures to certain environmental antibiotics may increase the risk of childhood obesity, especially in boys.
儿童暴露于环境抗生素是一个主要的公共卫生关注点。然而，关于环境抗生素暴露对儿童肥胖的影响的数据有限。我们的研究旨在探讨这种关系。我们进行了一项横断面病例对照研究，嵌套在一项基于人群的小学生调查中，包括 1855 名肥胖儿童和 1875 名随机选择的对照儿童。通过液相色谱-串联质谱法测量尿液样本中的 10 种抗生素。多变量调查逻辑回归用于评估环境抗生素暴露与儿童肥胖之间的关系。在调整了潜在的混杂因素后，暴露于四环素（OR=1.31，95%CI：1.09-1.57）和磺胺甲噁唑（OR=1.43，95%CI：1-2.05）的儿童肥胖的可能性增加。与无（<LOD）、低、中、高暴露组相比，磺胺甲噁唑低暴露与肥胖的可能性增加相关（OR=1.91，95%CI：1.05-3.47）。中水平暴露于四环素（OR=1.96，95%CI：1.05-3.66）、多西环素（OR=1.56，95%CI：1-2.46）和林可霉素（OR=1.35，95%CI：1.05-1.74）与肥胖的可能性增加相关。然而，在任何高水平抗生素暴露组中均未发现显著关联。这些显著关联主要在男孩中观察到。环境抗生素暴露与儿童肥胖之间的关系是非线性的。某些环境抗生素的低至中水平暴露可能会增加儿童肥胖的风险，尤其是在男孩中。
