Wang Junya, Geng Shijie, Yao Xiaodie, Wen Juan, Lu Renjie
Nanjing Maternity and Child Health Care Institute, Nanjing Women and Children's Healthcare Hospital, Women's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000, China.
Changzhou Medical Center, Changzhou Third People's Hospital, Nanjing Medical University, Changzhou, Jiangsu 213000, China.
Curr Pharm Des. 2025;31(12):934-942. doi: 10.2174/0113816128333496240911061551.
Childhood overweight and obesity are nutritional disorders in which children's energy intake exceeds energy consumption for a long period, resulting in the excessive accumulation of body fat and weight that exceeds a certain range. It is one of the most serious public health issues. In recent years, its prevalence has shown a significant upward trend, and 41-80% of childhood obesity can persist into adulthood. Scholars are now more interested in researching this further. Since antibiotics have been used extensively since their discovery, more focus has been paid to the possible risks these medications pose to children who are exposed to them. Recently, some studies have explored the possible link between antibiotic exposure and the prevalence of overweight and obesity in children. However, their findings are inconsistent. Therefore, this review aims to synthesize and summarize the studies related to the effects of antibiotics on childhood obesity, elucidate the possible associations between the two, and provide an in-depth discussion of the potential biological mechanisms by which antibiotics exposure may contribute to childhood obesity.
儿童超重和肥胖是营养失调症，即儿童长期能量摄入超过能量消耗，导致体脂过度积累，体重超过一定范围。这是最严重的公共卫生问题之一。近年来，其患病率呈显著上升趋势，41%至80%的儿童肥胖会持续到成年期。学者们现在对进一步研究这一问题更感兴趣。自从抗生素被发现以来被广泛使用，人们更多地关注这些药物对接触它们的儿童可能带来的风险。最近，一些研究探讨了抗生素暴露与儿童超重和肥胖患病率之间的可能联系。然而，他们的研究结果并不一致。因此，本综述旨在综合和总结与抗生素对儿童肥胖影响相关的研究，阐明两者之间可能的关联，并深入讨论抗生素暴露可能导致儿童肥胖的潜在生物学机制。
