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来自阿奇普雷瓦莱队列的HIV感染者与HIV阴性受试者的肌内膜中层厚度和动脉粥样斑块评估

Evaluation of Myo-Intimal Media Thickness and Atheromatous Plaques in People Living with HIV from the Archiprevaleat Cohort vs. HIV-Negative Subjects.

作者信息

Martini Salvatore, Ricci Elena Delfina, Masiello Addolorata, Zacà Sergio, Celesia Benedetto Maurizio, Ferrara Sergio, Di Filippo Giovanni, Tartaglia Alessandra, Basile Rosa, Angiletta Domenico, Maggi Paolo

机构信息

Department of Mental Health and Public Medicine, Section of Infectious Diseases, University of Campania, Luigi Vanvitelli, 80131 Naples, Italy.

Fondazione ASIA Onlus, 20090 Milan, Italy.

出版信息

Biomedicines. 2024 Apr 1;12(4):773. doi: 10.3390/biomedicines12040773.

DOI:10.3390/biomedicines12040773
PMID:38672129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11047944/
Abstract

BACKGROUND

Antiretroviral therapy has allowed a clear improvement in prognosis for HIV patients, but metabolic problems, such as dyslipidemia, remain. This can lead to the development of atheromatous plaques. Our study aims to evaluate whether HIV-positive (HIV+) patients show higher myo-intimal media thickness (IMT) and atheromatous plaques compared to HIV-negative (HIV-) patients.

METHODS

To evaluate the association between HIV infection in experienced patients and vascular pathology, we performed a cross-sectional study, observing 1006 patients, 380 HIV+ enrolled in the Archiprevaleat cohort, and 626 HIV- as a control group. All patients underwent a Doppler scan of the supra-aortic vessels. We compared the prevalence of IMT > 1.0 mm and plaques in the two groups.

RESULTS

Patients in the HIV+ group were younger than those in the HIV- group, with a lower prevalence of hypertension and diabetes and higher dyslipidemia. The prevalence of plaques in strata of age was higher in the HIV+ group than in the HIV- group and was associated with the length of ART exposure.

CONCLUSIONS

Our cross-sectional, retrospective study shows that HIV+ experienced patients are at greater risk of IMT and atheromatous plaques compared to HIV-. The risk is associated with being HIV+ and with the length of ART exposure. This finding may be useful in preventing cardiovascular risk.

摘要

背景

抗逆转录病毒疗法已使HIV患者的预后有了明显改善，但诸如血脂异常等代谢问题依然存在。这可能会导致动脉粥样硬化斑块的形成。我们的研究旨在评估与HIV阴性（HIV-）患者相比，HIV阳性（HIV+）患者的肌内膜中层厚度（IMT）和动脉粥样硬化斑块是否更高。

方法

为评估有经验的患者中HIV感染与血管病变之间的关联，我们进行了一项横断面研究，观察了1006例患者，其中380例HIV+患者纳入Archiprevaleat队列，626例HIV-患者作为对照组。所有患者均接受了主动脉弓上血管的多普勒扫描。我们比较了两组中IMT>1.0 mm和斑块的患病率。

结果

HIV+组患者比HIV-组患者年轻，高血压和糖尿病患病率较低，血脂异常患病率较高。HIV+组年龄分层中的斑块患病率高于HIV-组，且与抗逆转录病毒治疗暴露时间有关。

结论

我们的横断面回顾性研究表明，与HIV-患者相比，有经验的HIV+患者发生IMT和动脉粥样硬化斑块的风险更高。该风险与HIV+状态及抗逆转录病毒治疗暴露时间有关。这一发现可能有助于预防心血管风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ac/11047944/76d252abd5d6/biomedicines-12-00773-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ac/11047944/0ad71e12f2ef/biomedicines-12-00773-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ac/11047944/36446e90d5e1/biomedicines-12-00773-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ac/11047944/9d6f659831c8/biomedicines-12-00773-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ac/11047944/76d252abd5d6/biomedicines-12-00773-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ac/11047944/0ad71e12f2ef/biomedicines-12-00773-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ac/11047944/36446e90d5e1/biomedicines-12-00773-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ac/11047944/9d6f659831c8/biomedicines-12-00773-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ac/11047944/76d252abd5d6/biomedicines-12-00773-g004.jpg

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