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挥发性麻醉剂对大鼠急性间歇性低氧期间肾交感神经和膈神经活动的影响

The Effects of Volatile Anesthetics on Renal Sympathetic and Phrenic Nerve Activity during Acute Intermittent Hypoxia in Rats.

作者信息

Krnić Josip, Madirazza Katarina, Pecotić Renata, Benzon Benjamin, Carev Mladen, Đogaš Zoran

机构信息

Department of Emergency Medicine, University Hospital of Split, Spinčićeva 1, 21000 Split, Croatia.

Department of Anesthesiology, Reanimatology and Intensive Care Medicine, University Hospital of Split, Spinčićeva 1, 21000 Split, Croatia.

出版信息

Biomedicines. 2024 Apr 19;12(4):910. doi: 10.3390/biomedicines12040910.

DOI:10.3390/biomedicines12040910
PMID:38672264
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11048470/
Abstract

Coordinated activation of sympathetic and respiratory nervous systems is crucial in responses to noxious stimuli such as intermittent hypoxia. Acute intermittent hypoxia (AIH) is a valuable model for studying obstructive sleep apnea (OSA) pathophysiology, and stimulation of breathing during AIH is known to elicit long-term changes in respiratory and sympathetic functions. The aim of this study was to record the renal sympathetic nerve activity (RSNA) and phrenic nerve activity (PNA) during the AIH protocol in rats exposed to monoanesthesia with sevoflurane or isoflurane. Adult male Sprague-Dawley rats ( = 24; weight: 280-360 g) were selected and randomly divided into three groups: two experimental groups (sevoflurane group, = 6; isoflurane group, = 6) and a control group (urethane group, = 12). The AIH protocol was identical in all studied groups and consisted in delivering five 3 min-long hypoxic episodes (fraction of inspired oxygen, FiO = 0.09), separated by 3 min recovery intervals at FiO = 0.5. Volatile anesthetics, isoflurane and sevoflurane, blunted the RSNA response to AIH in comparison to urethane anesthesia. Additionally, the PNA response to acute intermittent hypoxia was preserved, indicating that the respiratory system might be more robust than the sympathetic system response during exposure to acute intermittent hypoxia.

摘要

交感神经系统和呼吸神经系统的协同激活在对诸如间歇性低氧等有害刺激的反应中至关重要。急性间歇性低氧（AIH）是研究阻塞性睡眠呼吸暂停（OSA）病理生理学的一个有价值的模型，并且已知在AIH期间刺激呼吸会引起呼吸和交感神经功能的长期变化。本研究的目的是记录在接受七氟烷或异氟烷单麻醉的大鼠的AIH方案期间的肾交感神经活动（RSNA）和膈神经活动（PNA）。选择成年雄性Sprague-Dawley大鼠（n = 24；体重：280 - 360 g）并随机分为三组：两个实验组（七氟烷组，n = 6；异氟烷组，n = 6）和一个对照组（乌拉坦组，n = 12）。所有研究组的AIH方案相同，包括给予五个3分钟长的低氧发作（吸入氧分数，FiO₂ = 0.09），中间间隔3分钟的FiO₂ = 0.5的恢复间隔。与乌拉坦麻醉相比，挥发性麻醉剂异氟烷和七氟烷减弱了RSNA对AIH的反应。此外，PNA对急性间歇性低氧的反应得以保留，表明在暴露于急性间歇性低氧期间呼吸系统可能比交感神经系统反应更稳健。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3882/11048470/1fcbbcea5467/biomedicines-12-00910-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3882/11048470/ed5abf758bed/biomedicines-12-00910-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3882/11048470/c34e6f0ae703/biomedicines-12-00910-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3882/11048470/47ba431c9e80/biomedicines-12-00910-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3882/11048470/1fcbbcea5467/biomedicines-12-00910-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3882/11048470/ed5abf758bed/biomedicines-12-00910-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3882/11048470/c34e6f0ae703/biomedicines-12-00910-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3882/11048470/57e7f43537a3/biomedicines-12-00910-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3882/11048470/47ba431c9e80/biomedicines-12-00910-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3882/11048470/1fcbbcea5467/biomedicines-12-00910-g005.jpg

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