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早发性胃肠道恶性肿瘤：对一个日益受到关注的问题的调查

Early-Onset Gastrointestinal Malignancies: An Investigation into a Rising Concern.

作者信息

Vishwanath Aayush, Krishna Shreyas, Manudhane Albert P, Hart Phil A, Krishna Somashekar G

机构信息

Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA.

Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University, Columbus, OH 43210, USA.

出版信息

Cancers (Basel). 2024 Apr 18;16(8):1553. doi: 10.3390/cancers16081553.

DOI:10.3390/cancers16081553
PMID:38672634
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11049592/
Abstract

There is growing recognition of early-onset gastrointestinal (GI) malignancies in young adults < 50 years of age. While much of the literature has emphasized colorectal cancer, these also include esophageal, gastric, liver, pancreatic, and biliary tract malignancies. Various factors, including lifestyle, hereditary, and environmental elements, have been proposed to explain the rising incidence of GI malignancies in the younger population. This review aims to provide an overview of the recent literature, including global trends and information regarding genetic and environmental risk factors.

摘要

50岁以下的年轻成年人中早发性胃肠道（GI）恶性肿瘤越来越受到关注。虽然大部分文献都强调结直肠癌，但这些还包括食管癌、胃癌、肝癌、胰腺癌和胆道恶性肿瘤。人们提出了包括生活方式、遗传和环境因素在内的各种因素来解释年轻人群中胃肠道恶性肿瘤发病率的上升。这篇综述旨在概述近期文献，包括全球趋势以及有关遗传和环境风险因素的信息。

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Early-Onset Gastrointestinal Malignancies: An Investigation into a Rising Concern.

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[8]
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[2]
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[3]
Comprehensive molecular analysis of early‑onset gastric cancer identifies novel genes implicated in disease characterization and progression (Review).

Oncol Rep. 2025-8

[4]
Informatics strategies for early detection and risk mitigation in pancreatic cancer patients.

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[5]
Comparison of postoperative survival prognosis between early-onset and late-onset esophageal cancer: A Population-based study.

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[6]
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[7]
State-of-the-art cytometry in the search of novel biomarkers in digestive cancers.

Front Oncol. 2024-5-29

本文引用的文献

[1]
Cancer statistics, 2024.

CA Cancer J Clin. 2024

[2]
Rising Incidence of Pancreatic Cancer in Patients 20 to 39 Years: A Population-Based Observational Study.

Pancreas. 2023-3-1

[3]
Updated Perspectives on the Diagnosis and Management of Familial Adenomatous Polyposis.

Appl Clin Genet. 2023-8-14

[4]
Patterns in Cancer Incidence Among People Younger Than 50 Years in the US, 2010 to 2019.

JAMA Netw Open. 2023-8-1

[5]
Risk factors for early-onset colorectal cancer: systematic review and meta-analysis.

Front Oncol. 2023-5-5

[6]
Colorectal cancer statistics, 2023.

CA Cancer J Clin. 2023

[7]
Clinical characteristics, treatment patterns and survival outcomes of early-onset pancreatic adenocarcinoma: a population-based study.

Am J Transl Res. 2023-1-15

[8]
Early-Onset Cancer in the Gastrointestinal Tract Is on the Rise-Evidence and Implications.

Cancer Discov. 2023-3-1

[9]
Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN.

Gut. 2023-2

[10]
Trends in Esophageal Adenocarcinoma and Esophageal Squamous Cell Carcinoma Incidence in the United States from 1992 to 2019.

Cancers (Basel). 2022-12-8

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