肥胖儿童超声检查结果与血清铁和铁蛋白水平的相关性

Associations of Ultrasound Findings with Serum Iron and Ferritin Levels in Children with Obesity.

作者信息

Stepan Mioara Desdemona, Vintilescu Ștefănița Bianca, Ionele Claudiu Marinel, Dumitra Gheorghe Gindrovel, Podeanu Mihaela Andreea, Bigea Camelia Cristiana, Sacerdoțianu Victor Mihai, Anastasescu Cătălina Mihaela, Florescu Dan Nicolae

机构信息

Department of Infant Care-Pediatrics-Neonatology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.

Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy Craiova, 200349 Craiova, Romania.

出版信息

Life (Basel). 2024 Apr 7;14(4):484. doi: 10.3390/life14040484.

Abstract

The nutritional status of children is always a concern for medical professionals. Increasingly, obesogenic factors have created a new global epidemic. Obesity is characterized by persistent inflammation, which can have detrimental effects on the growth and development of children. Iron and ferritin are both important factors to consider when evaluating these children due to their role in the pathophysiology of chronic inflammation. Recently, ultrasonographic evaluation seems to be an increasingly used method in pediatric clinical practice. In this study, we included 98 children aged 6-14 years, 72 of whom were obese and 26 had normal weight. The data obtained indicated that there was an association between low iron and increased ferritin levels, aspects of non-alcoholic fatty liver visualized by ultrasonography, and the degree of fibrosis assessed elastographically. Ultrasonography can help us identify liver damage, but the possibility of identifying an association with other paraclinical investigations such as iron and ferritin levels can be cumulative. In this way, the assessment can be more complex, as the child benefits from comprehensive evaluation and management. The results drew attention to non-invasive, easy-to-perform, and low-cost methods of assessing obese children in terms of iron metabolism and structural liver changes.

摘要

儿童的营养状况一直是医学专业人员关注的问题。致肥胖因素日益引发了一场新的全球流行病。肥胖的特征是持续炎症,这可能对儿童的生长发育产生不利影响。由于铁和铁蛋白在慢性炎症的病理生理学中发挥作用,因此在评估这些儿童时,它们都是需要考虑的重要因素。最近,超声评估似乎在儿科临床实践中越来越常用。在本研究中,我们纳入了98名6至14岁的儿童,其中72名肥胖,26名体重正常。获得的数据表明,低铁与铁蛋白水平升高、超声显示的非酒精性脂肪肝情况以及通过弹性成像评估的纤维化程度之间存在关联。超声检查可以帮助我们识别肝脏损伤,但识别与铁和铁蛋白水平等其他辅助临床检查之间关联的可能性可能是累积性的。这样一来,评估可能会更加复杂,因为儿童受益于全面的评估和管理。这些结果让人们注意到在评估肥胖儿童的铁代谢和肝脏结构变化方面,有非侵入性、易于实施且成本低廉的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2866/11051232/af0a3898d001/life-14-00484-g001.jpg

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