Pontifícia Universidade Católica de Campinas (PUC-Campinas), Campinas, SP, Brazil.
Pontifícia Universidade Católica de Campinas (PUC-Campinas), Campinas, SP, Brazil.
J Pediatr (Rio J). 2024 Mar-Apr;100(2):124-131. doi: 10.1016/j.jped.2023.06.002. Epub 2023 Aug 1.
This paper aims to review data on the association of obesity and iron deficiency in children and adolescents, exposing the possible involvement of hepcidin and interleukin-6 (IL-6), obesity's inflammation biomarkers.
Articles from PUBMED and WEB OF SCIENCE database with no chronological limit were reviewed to write this systematic review. Keywords such as children, obesity, iron deficiency, and hepcidin were used. After deleting duplicated and review articles, 91 were screened, and 39 were selected as eligible. Sixteen articles were included because they involved serum hepcidin levels in obese children and adolescents as outcomes.
Finally, those 16 articles were organized in two tables: one includes therapeutic interventions, and the other does not. As hepcidin was discovered in 2000, the first articles that presented serum hepcidin's quantification in obese children and adolescents, homeostasis iron markers, and their possible association with obesity's inflammatory environment began to be published in 2008.
Obesity's chronic inflammation state leads to the production of IL-6, which acts as a signaling molecule for hepcidin synthesis, resulting in iron deficiency, which is common in obese children and adolescents who respond inadequately to iron supplementation. On the other hand, that population responds adequately to therapeutic intervention programs that lead to weight loss, guaranteeing iron homeostasis improvement. Therefore, perhaps it is time to discuss serum hepcidin level quantification as part of evaluating children and adolescents with iron deficiency, which could guide clinical choices that might lead to better therapeutic outcomes.
本文旨在回顾肥胖与儿童和青少年铁缺乏症之间关联的数据，揭示铁调素和白细胞介素-6（IL-6）可能参与其中，这两种物质都是肥胖症的炎症生物标志物。
为撰写这篇系统评价，我们查阅了 PUBMED 和 WEB OF SCIENCE 数据库中没有时间限制的文章。使用了“儿童、肥胖、铁缺乏症和铁调素”等关键词。删除重复和综述文章后，共筛选出 91 篇文章，其中 39 篇符合入选标准。有 16 篇文章因涉及肥胖儿童和青少年的血清铁调素水平作为研究结果而被纳入。
最终，这 16 篇文章被组织成两个表格：一个表格包括治疗干预措施，另一个表格则不包括。铁调素于 2000 年被发现，因此，2008 年才开始发表第一篇报告肥胖儿童和青少年血清铁调素定量、铁稳态标志物及其与肥胖症炎症环境之间可能存在关联的文章。
肥胖症的慢性炎症状态导致白细胞介素-6（IL-6）的产生，作为铁调素合成的信号分子，导致铁缺乏症，这在对铁补充反应不足的肥胖儿童和青少年中很常见。另一方面，这些人群对导致体重减轻的治疗干预方案有适当的反应，从而保证铁稳态的改善。因此，也许现在应该讨论将血清铁调素水平的定量作为评估铁缺乏症儿童和青少年的一部分，这可以指导临床选择，从而可能带来更好的治疗效果。
