Voros Charalampos, Bananis Kyriakos, Papapanagiotou Angeliki, Pouliakis Abraham, Mavriki Konstantina, Gkaniatsos Ioannis, Daskalaki Maria Anastasia, Prokopakis Ioannis, Tsimpoukelis Charalampos, Koulakmanidis Aristotelis-Marios, Darlas Menelaos, Anysiadou Sofia, Daskalakis Georgios, Domali Ekaterini
1st Department of Obstetrics and Gynecology, 'Alexandra' General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece.
Ealing Hospital, London North West University Healthcare NHS Trust, 601 Uxbridge Road, Southall UB1 3HW, UK.
J Clin Med. 2024 Apr 13;13(8):2261. doi: 10.3390/jcm13082261.
This study investigates links between CART and leptin gene expression, FSH receptor Asn680Ser polymorphism, and reproductive hormones in morbidly obese patients under 40 years old, facing infertility, and undergoing bariatric surgery. A total of 29 women were included in this study. A hormonal profile along with detection of CART and leptin gene expression was evaluated before and after bariatric surgery. Additionally, the presence or absence of Asn680Ser of the gene was studied. Following bariatric surgery, a mean reduction in BMI (16.03 kg/m) was observed in all women. FSH levels preoperatively varied significantly among genotypes, with medians of 8.1, 9.5, and 10.3 for individuals without polymorphism, heterozygotes, and homozygotes, respectively ( = 0.0408). Post surgery, marginal differences in FSH levels were observed (5.8, 7.1, and 8.2, respectively) ( = 0.0356). E2 and LH levels exhibited no significant genotype-based differences pre and post surgery. Presurgical E2 levels were 29.6, 29.8, and 29.6, respectively ( = 0.91634), while postsurgical levels were 51.2, 47.8, and 47 ( = 0.7720). LH levels followed similar patterns. Our findings highlight bariatric surgery's positive impact on BMI reduction and its potential connection to genetic markers, hormones, and infertility. This suggests personalized treatments and offers a valuable genetic tool for better fertility outcomes in obese individuals.
本研究调查了40岁以下、面临不孕且接受减肥手术的病态肥胖患者中，可卡因-安非他明调节转录肽（CART）与瘦素基因表达、促卵泡激素（FSH）受体Asn680Ser多态性及生殖激素之间的联系。本研究共纳入了29名女性。在减肥手术前后评估了激素水平以及CART和瘦素基因表达的检测情况。此外，还研究了该基因Asn680Ser的有无情况。减肥手术后，所有女性的体重指数（BMI）平均下降了16.03kg/m²。术前FSH水平在不同基因型之间有显著差异，无多态性个体、杂合子和纯合子的中位数分别为8.1、9.5和10.3（P = 0.0408）。术后，FSH水平存在微小差异（分别为5.8、7.1和8.2）（P = 0.0356）。雌二醇（E2）和促黄体生成素（LH）水平在手术前后均未表现出基于基因型的显著差异。术前E2水平分别为29.6、29.8和29.6（P = 0.91634），而术后水平分别为51.2、47.8和47（P = 0.7720）。LH水平呈现类似模式。我们的研究结果突出了减肥手术对降低BMI的积极影响及其与遗传标记、激素和不孕的潜在联系。这表明了个性化治疗的可能性，并为肥胖个体改善生育结局提供了一种有价值的遗传工具。
