Voros Charalampos, Mpananis Kyriakos, Papapanagiotou Angeliki, Pouliakis Abraham, Mavrogianni Despoina, Mavriki Konstantina, Gkaniatsos Ioannis, Karasmani Christina, Prokopakis Ioannis, Darlas Menelaos, Anysiadou Sofia, Daskalakis George, Domali Ekaterini
1st Department of Obstetrics and Gynecology, 'Alexandra' General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 115 28 Athens, Greece.
Ealing Hospital, London North West University Healthcare NHS Trust, 601 Uxbridge Road, Southall UB1 3HW, UK.
J Clin Med. 2024 Feb 18;13(4):1146. doi: 10.3390/jcm13041146.
Obesity, a global health concern affecting 650 million individuals of all ages worldwide, prompts health complications, including fertility issues. This research investigates the impact of bariatric surgery on morbidly obese females under 40, examining the relationship between CART and leptin gene expressions and reproductive hormones. Post-surgery, a significant reduction in BMI (16.03 kg/m, n = 29) was observed, accompanied by notable hormonal changes. FSH levels showed a mean difference of 3.18 ± 1.19 pre- and post-surgery ( < 0.001), LH levels exhibited a mean difference of 2.62 ± 1.1 ( < 0.001), E2 levels demonstrated a mean difference of 18.62 ± 5.02 ( < 0.001), and AMH levels showed a mean difference of 3.18 ± 1.19 ( < 0.001). High CART and leptin expressions before treatment correlated with lower expressions after treatment. These findings, rooted in statistically significant correlations (CART: rs = 0.51, = 0.005; leptin: rs = 0.75, < 0.001), shed light on potential molecular pathways connecting gene expressions with reproductive hormones post-bariatric surgery. Our study uniquely investigates the interplay between genetic markers, infertility, and bariatric surgery in women. It stands out by providing distinctive insights into the development of personalized treatment strategies for obesity-related infertility, contributing to a deeper understanding of this complex medical issue.
肥胖是一个全球健康问题，影响着全球6.5亿各年龄段的人，会引发包括生育问题在内的健康并发症。本研究调查了减肥手术对40岁以下病态肥胖女性的影响，研究了可卡因-安非他明调节转录肽（CART）和瘦素基因表达与生殖激素之间的关系。手术后，观察到体重指数显著降低（16.03 kg/m，n = 29），同时伴随着明显的激素变化。促卵泡生成素（FSH）水平在术前和术后的平均差异为3.18±1.19（<0.001），促黄体生成素（LH）水平的平均差异为2.62±1.1（<0.001），雌二醇（E2）水平的平均差异为18.62±5.02（<0.001），抗苗勒管激素（AMH）水平的平均差异为3.18±1.19（<0.001）。治疗前高CART和瘦素表达与治疗后较低表达相关。这些基于统计学显著相关性的发现（CART：rs = 0.51，P = 0.005；瘦素：rs = 0.75，P < 0.001）揭示了减肥手术后将基因表达与生殖激素联系起来的潜在分子途径。我们的研究独特地调查了女性基因标记、不孕症和减肥手术之间的相互作用。它通过为肥胖相关不孕症的个性化治疗策略的制定提供独特见解而脱颖而出，有助于更深入地理解这一复杂的医学问题。
