Croitoru Cristina Georgiana, Pavel-Tanasa Mariana, Cuciureanu Dan Iulian, Hodorog Diana Nicoleta, Cianga Petru
I Neurology Clinic, "Prof. Dr. Nicolae Oblu" Emergency Clinical Hospital, 700309 Iași, Romania.
Department of Immunology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.
J Clin Med. 2024 Apr 14;13(8):2273. doi: 10.3390/jcm13082273.
As the life expectancy of patients with myasthenia gravis (MG) is improving, so the number of comorbidities continues to rise, with a potentially significant impact on the overall morbidity and mortality. The main aim of the study was to assess comorbidities of MG in a group of patients of East-European descent. We retrospectively compared 185 adult myasthenic patients with 895 sex- and age-matched controls, admitted from January 2013 to December 2021. Of these patients, 60% had late-onset MG (LOMG), with a clear predominance of women in both the LOMG and early-onset (EOMG) types; and 23.8% of the patients had a radiological description consistent with thymoma. All myasthenic patients had at least one comorbidity; 20 (10.8%) of the patients associated at least one autoimmune comorbidity. Obesity ( < 0.01), type 2 diabetes ( < 0.0001), cerebrovascular diseases ( < 0.0001), essential hypertension ( < 0.01), and cardiac arrythmias ( < 0.0001) were more frequent in patients than in the control group. The granulocyte-to-lymphocyte ratio was higher in the myasthenic patients compared to the controls ( < 0.01 for LOMG). We, thus, suggest a common chronic low-grade inflammatory background as a possible connection between MG subtypes and some of these apparently unconnected comorbidities. The East-European origin of the patients offered a different social and cultural angle of a disease studied mainly on populations of West-European and Asian descent.
随着重症肌无力（MG）患者预期寿命的延长，其合并症数量也在持续增加，这对总体发病率和死亡率可能产生重大影响。本研究的主要目的是评估一组东欧血统患者的MG合并症情况。我们回顾性比较了2013年1月至2021年12月收治的185例成年肌无力患者和895例性别及年龄匹配的对照者。在这些患者中，60%患有迟发性MG（LOMG），在LOMG和早发性（EOMG）类型中女性均明显占主导；23.8%的患者有与胸腺瘤一致的影像学描述。所有肌无力患者至少有一种合并症；20例（10.8%）患者至少有一种自身免疫性合并症。肥胖（<0.01）、2型糖尿病（<0.0001）、脑血管疾病（<0.0001）、原发性高血压（<0.01）和心律失常（<0.0001）在患者中比对照组更常见。与对照组相比，肌无力患者的粒细胞与淋巴细胞比值更高（LOMG为<0.01）。因此，我们认为常见的慢性低度炎症背景可能是MG亚型与其中一些明显无关的合并症之间的联系。患者的东欧血统为主要在西欧和亚洲血统人群中研究的疾病提供了不同的社会和文化视角。
