Blitshteyn Svetlana, Lange Anna, Corinaldi Chelsea, Guy Paige, Brook Jill
Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA.
Dysautonomia Clinic, Williamsville, NY 14221, USA.
J Clin Med. 2024 Apr 14;13(8):2274. doi: 10.3390/jcm13082274.
We aimed to determine whether patients with postural orthostatic tachycardia syndrome (POTS) have sexual dysfunction compared to age-matched healthy controls. Utilizing online COMPASS-31 to evaluate dysautonomia symptom severity, Beck's Depression Inventory Second Edition (BDII), Female Sexual Function (FSF), and International Index of Erection Function (IIEF) questionnaires, we compared sexual function scores in patients with POTS to scores obtained from sex- and age-matched healthy controls via a cross-sectional case-control study. A total of 160 women with POTS, mean age 30.2 ± 7.9 (range 21-50 years), had lower FSF scores than 62 healthy age-matched female controls. IIEF scores in 29 male patients with POTS with a mean age of 30.1 ± 6.0 (range 21-47) were significantly lower than in 27 healthy age-matched male controls. Female POTS patients had significantly lower scores in the sub-domains of desire, arousal, and satisfaction, while male POTS patients had significantly lower scores in erectile and orgasmic function, desire, and satisfaction than healthy controls. Predictive factors of sexual dysfunction were depression in women and age in men. The severity of autonomic symptoms correlated with sexual dysfunction in women, but this effect disappeared after controlling for depression. Compared to healthy controls, women and men with POTS have significant sexual dysfunction, which needs to be considered in the diagnostic and therapeutic approaches as part of comprehensive patient care.
我们旨在确定与年龄匹配的健康对照相比，体位性直立性心动过速综合征（POTS）患者是否存在性功能障碍。通过横断面病例对照研究，利用在线COMPASS-31评估自主神经功能障碍症状严重程度、贝克抑郁量表第二版（BDII）、女性性功能（FSF）和勃起功能国际指数（IIEF）问卷，我们比较了POTS患者的性功能评分与性别和年龄匹配的健康对照者的评分。共有160名POTS女性患者，平均年龄30.2±7.9岁（范围21 - 50岁），其FSF评分低于62名年龄匹配的健康女性对照者。29名平均年龄为30.1±6.0岁（范围21 - 47岁）的POTS男性患者的IIEF评分显著低于27名年龄匹配的健康男性对照者。女性POTS患者在性欲、性唤起和性满意度子领域的得分显著更低，而男性POTS患者在勃起功能、性高潮功能、性欲和性满意度方面的得分显著低于健康对照者。性功能障碍的预测因素在女性中是抑郁，在男性中是年龄。自主神经症状的严重程度与女性性功能障碍相关，但在控制抑郁后这种效应消失。与健康对照相比，POTS女性和男性均存在显著的性功能障碍，在诊断和治疗方法中作为综合患者护理的一部分需要考虑这一点。
