Bayonas-Ruiz Adrián, Muñoz-Franco Francisca M, Sabater-Molina María, Martínez-González-Moro Ignacio, Gimeno-Blanes Juan Ramon, Bonacasa Bárbara
Department of Physiology, Human Physiology Area, Sports Sciences Faculty, University of Murcia, C. Argentina, 19, 30720 San Javier, Murcia, Spain.
Research Group of Physical Exercise and Human Performance, University of Murcia, 30720 San Javier, Murcia, Spain.
J Clin Med. 2024 Apr 17;13(8):2324. doi: 10.3390/jcm13082324.
Exercise training in patients with HCM has evidenced benefits on functional capacity, cardiac function, and a reversion of adverse cardiac remodeling. The objective of this study was to assess the effect of a concurrent resistance and cardiorespiratory training program on functional capacity, biochemical parameters, and echocardiographic variables in a pilot group. Two HCM patients were evaluated before and after 12 weeks of individualized concurrent training with two sessions/week. Pre- and post-training data were compared for each patient. Evaluations included a cardiopulmonary exercise test (CPET), body composition, echocardiography, electrocardiography, and blood analysis. Training promoted an increase in functional capacity (+4 mL·kg·min), ventilatory thresholds, and other CPET-derived variables associated with a better prognosis and long-term survival. Muscular mass was augmented (0.8 and 1.2 kg), along with a mean increase of 62% in upper and lower body strength. Echocardiographic features demonstrated the maintenance of cardiac function with signs of positive left ventricular remodeling and an improvement in diastolic function. Blood analyses, including cardiac troponins and NT-proBNP, displayed uneven changes in each patient, but the values fell into normal ranges in both cases. The available data suggest a positive effect of concurrent resistance and cardiorespiratory training on patients' functional capacity and cardiac function that may improve their functional class, quality of life, and long-term prognosis. The replication of this protocol in a larger cohort of patients is warranted to confirm these preliminary results.
对肥厚型心肌病（HCM）患者进行运动训练已证明对功能能力、心脏功能以及逆转不良心脏重塑有益。本研究的目的是评估一项同步抗阻和心肺训练计划对一个试点组患者的功能能力、生化参数和超声心动图变量的影响。两名HCM患者在每周进行两次个体化同步训练，为期12周前后接受了评估。对每位患者训练前后的数据进行了比较。评估包括心肺运动试验（CPET）、身体成分、超声心动图、心电图和血液分析。训练促进了功能能力（+4 mL·kg·min）、通气阈值以及其他与更好预后和长期生存相关的CPET衍生变量的增加。肌肉量增加（分别为0.8 kg和1.2 kg），上下肢力量平均增加62%。超声心动图特征显示心脏功能得以维持，伴有左心室正向重塑迹象以及舒张功能改善。血液分析，包括心肌肌钙蛋白和N末端B型利钠肽原（NT-proBNP），在每位患者中显示出不均衡变化，但在两种情况下数值均降至正常范围。现有数据表明同步抗阻和心肺训练对患者的功能能力和心脏功能有积极影响，可能改善其心功能分级、生活质量和长期预后。有必要在更大规模的患者队列中重复此方案以证实这些初步结果。
