Kukucka Tomas, Ferencova Nikola, Visnovcova Zuzana, Ondrejka Igor, Hrtanek Igor, Kovacova Veronika, Macejova Andrea, Mlyncekova Zuzana, Tonhajzerova Ingrid
Clinic of Psychiatry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, University Hospital Martin, 03659 Martin, Slovakia.
Biomedical Centre Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 03601 Martin, Slovakia.
Int J Mol Sci. 2024 Apr 20;25(8):4511. doi: 10.3390/ijms25084511.
Major depressive disorder is a severe mood disorder associated with a marked decrease in quality of life and social functioning, accompanied by a risk of suicidal behavior. Therefore, seeking out and adhering to effective treatment is of great personal and society-wide importance. Weight changes associated with antidepressant therapy are often cited as the reason for treatment withdrawal and thus are an important topic of interest. There indeed exists a significant mechanistic overlap between depression, antidepressant treatment, and the regulation of appetite and body weight. The suggested pathomechanisms include the abnormal functioning of the homeostatic (mostly humoral) and hedonic (mostly dopaminergic) circuits of appetite regulation, as well as causing neuromorphological and neurophysiological changes underlying the development of depressive disorder. However, this issue is still extensively discussed. This review aims to summarize mechanisms linked to depression and antidepressant therapy in the context of weight change.
重度抑郁症是一种严重的情绪障碍，与生活质量和社会功能显著下降相关，并伴有自杀行为风险。因此，寻找并坚持有效的治疗方法具有重大的个人和社会意义。与抗抑郁治疗相关的体重变化常被视为停药的原因，因此是一个重要的关注话题。抑郁症、抗抑郁治疗以及食欲和体重调节之间确实存在显著的机制重叠。所提出的病理机制包括食欲调节的稳态（主要是体液）和享乐（主要是多巴胺能）回路功能异常，以及导致抑郁症发展的神经形态学和神经生理学变化。然而，这个问题仍在广泛讨论中。本综述旨在总结在体重变化背景下与抑郁症和抗抑郁治疗相关的机制。
