Ziętek Maciej, Świątkowska-Feund Małgorzata, Ciećwież Sylwester, Machałowski Tomasz, Szczuko Małgorzata
Department of Perinatology, Obstetrics and Gynecology, Pomeranian Medical University, 71-010 Police, Poland.
The Academy of Applied Medical and Social Sciences, 82-300 Elbląg, Poland.
Medicina (Kaunas). 2024 Apr 18;60(4):651. doi: 10.3390/medicina60040651.
: Wound healing encompasses a multitude of factors and entails the establishment of interactions among components of the basement membrane. The quantification of particle concentrations can serve as valuable biomarkers for assessing biomechanical muscle properties. The objective of this study was to examine the immunoexpression and immunoconcentration of myometrial collagen type VI, elastin, alpha-smooth muscle actin, and smooth muscle myosin heavy chain, as well as the expression of platelets and clusters of differentiation 31 in the uterine scar following a cesarean section (CS). : A total of 177 biopsies were procured from a cohort of pregnant women who were healthy, specifically during the surgical procedure of CS. The participants were categorized into seven distinct groups. Group 1 consisted of primiparas, with a total of 52 individuals. The subsequent groups were organized based on the duration of time that had elapsed since their previous CS. The analysis focused on the immunoexpression and immunoconcentration of the particles listed. : No significant variations were observed in the myometrial immunoconcentration of collagen type VI, elastin, smooth muscle myosin, and endothelial cell cluster of differentiation 31 among the analyzed groups. The concentration of alpha-smooth muscle actin in the myometrium was found to be significantly higher in patients who underwent CS within a period of less than 2 years since their previous CS, compared to those with a longer interval between procedures. : Our findings indicate that the immunoconcentration of uterine myometrial scar collagen type VI, elastin, smooth muscle myosin heavy chain, alpha-smooth muscle actin, and endothelial cell marker cluster of differentiation 31 remains consistent regardless of the duration elapsed since the previous CS. The findings indicate that there are no significant alterations in the biomechanical properties of the uterine muscle beyond a period of 13 months following a CS.
伤口愈合涉及多种因素，需要基底膜各成分之间建立相互作用。颗粒浓度的量化可作为评估生物力学肌肉特性的有价值的生物标志物。本研究的目的是检测剖宫产术后子宫瘢痕中子宫肌层Ⅵ型胶原、弹性蛋白、α-平滑肌肌动蛋白和平滑肌肌球蛋白重链的免疫表达和免疫浓度，以及血小板和分化簇31的表达。：从一组健康孕妇中总共获取了177份活检样本，具体是在剖宫产手术过程中获取的。参与者被分为七个不同的组。第1组由初产妇组成，共有52人。随后的组是根据距上次剖宫产术后经过的时间来组织的。分析集中在所列颗粒的免疫表达和免疫浓度上。：在所分析的组中，子宫肌层Ⅵ型胶原、弹性蛋白、平滑肌肌球蛋白和内皮细胞分化簇31的免疫浓度未观察到显著差异。与手术间隔时间较长的患者相比，上次剖宫产术后不到2年进行剖宫产的患者子宫肌层中α-平滑肌肌动蛋白的浓度显著更高。：我们的研究结果表明，无论距上次剖宫产术后经过的时间长短，子宫肌层瘢痕Ⅵ型胶原、弹性蛋白、平滑肌肌球蛋白重链、α-平滑肌肌动蛋白和内皮细胞标志物分化簇31的免疫浓度保持一致。研究结果表明，剖宫产术后13个月后子宫肌肉的生物力学特性没有显著改变。
