Lindo Cherry Erlin, Sebastian James, Kuntjoro Karina Natalie, Halim Valencia Audrey, Tadjoedin Fatimah Maria, Kuswandani Sandra Olivia, Sulijaya Benso
Periodontology Specialist Program, Department of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta Pusat 10430, Indonesia.
Department of Periodontology, Faculty of Dentistry, Universitas Indonesia, Salemba Raya No. 4, Jakarta Pusat 10430, Indonesia.
Medicina (Kaunas). 2024 Apr 21;60(4):672. doi: 10.3390/medicina60040672.
Periodontitis is a disease linked to severe dysbiosis of the subgingival microbiome. The treatment of periodontitis aims to change the dysbiosis environment to a symbiosis environment. We hypothesized that oral microbiota transplantation can lead to a significant improvement in periodontitis. Therefore, the aim of this study was to determine the effectiveness of microbiota transplantation after standard periodontal treatment in periodontitis patients. The search strategy was carried out by using the Boolean term "AND" to combine the keywords, which were "periodontitis AND microbiota transplantation". Due to the limited resources of the study, we included both in vitro and in vivo investigations in this systematic review. The QUIN risk of bias tool was employed to assess the risk of bias in in vitro studies, while SYRCLE's risk of bias assessment was used for in vivo studies. Oral microbiota transplants (OMTs) have shown potential in treating periodontitis. OMTs significantly reduced periodontitis-associated pathogenic microbial species (, , sp.) and increased beneficial bacteria (, , , , , and upon in vitro testing. Furthermore, in the in vivo tests, single adjunctive OMT also had an effect on the oral microbiota composition compared to the full-mouth mechanical and antimicrobial debridement. OMTs may be cheaper and more effective at addressing high-risk individuals. At present, it is not possible to provide OMT clinical advice due to the lack of available information. This treatment needs to be subjected to more safety and efficacy testing before being included human clinical trials.
牙周炎是一种与龈下微生物群严重失调相关的疾病。牙周炎的治疗旨在将失调的环境转变为共生环境。我们假设口腔微生物群移植可显著改善牙周炎。因此，本研究的目的是确定牙周炎患者在接受标准牙周治疗后进行微生物群移植的有效性。检索策略是使用布尔运算符“AND”来组合关键词，即“牙周炎 AND 微生物群移植”。由于本研究资源有限，我们在该系统评价中纳入了体外和体内研究。采用 QUIN 偏倚风险工具评估体外研究的偏倚风险，而 SYRCLE 的偏倚风险评估用于体内研究。口腔微生物群移植（OMT）已显示出治疗牙周炎的潜力。体外测试显示，OMT 显著减少了与牙周炎相关的致病微生物种类（……菌属），并增加了有益细菌（……菌属）。此外，在体内测试中，与全口机械和抗菌清创术相比，单次辅助 OMT 对口腔微生物群组成也有影响。OMT 在治疗高危个体方面可能更便宜且更有效。目前，由于缺乏可用信息，无法提供 OMT 的临床建议。在纳入人体临床试验之前，这种治疗方法需要进行更多的安全性和有效性测试。
