Bouloukaki Izolde, Christodoulakis Antonios, Papageorgakopoulou Stavroula, Tsiligianni Ioanna
Department of Social Medicine, School of Medicine, University of Crete, 71003 Heraklion, Greece.
Department of Nursing, School of Health Sciences, Hellenic Mediterranean University, 71410 Heraklion, Greece.
Vaccines (Basel). 2024 Apr 14;12(4):414. doi: 10.3390/vaccines12040414.
The emergence of novel coronavirus mutations and signs of the waning immunity provided by COVID-19 vaccines underscore the importance of regular vaccination. This study aimed to investigate the prevalence of regular COVID-19 vaccination hesitancy and the factors that influence it among patients with asthma or chronic obstructive pulmonary disease (COPD) who visited primary care centers. The cross-sectional study was conducted in six primary healthcare centers in Crete, Greece (October-December 2023). Participants completed a questionnaire, which included questions about socio-demographic characteristics, health status, previous COVID-19 booster vaccination, attitudes, and beliefs about COVID-19 vaccination. Multivariate logistic regression was used to identify the factors that influenced vaccine hesitancy. Of the 264 participants, 65% exhibited hesitancy towards COVID-19 booster vaccination. Female gender, middle age, lower educational attainment, depression diagnosis, concerns about vaccine side effects, lack of confidence in vaccine efficacy, and reliance on media information were positively associated to vaccine hesitancy. Conversely, those having a cardiovascular disease or type 2 diabetes, those generally adhering to the recommendations of the treating physician, and those having previously received the flu vaccine or more than three COVID-19 vaccine doses were positively associated with regular COVID-19 vaccinations. Consequently, our findings could help develop strategies that could potentially reduce regular vaccination hesitancy among patients with asthma or COPD.
新型冠状病毒变异的出现以及新冠疫苗所提供的免疫力减弱迹象凸显了定期接种疫苗的重要性。本研究旨在调查在初级保健中心就诊的哮喘或慢性阻塞性肺疾病（COPD）患者中定期接种新冠疫苗的犹豫率及其影响因素。这项横断面研究于2023年10月至12月在希腊克里特岛的六个初级医疗保健中心进行。参与者完成了一份问卷，其中包括有关社会人口学特征、健康状况、之前的新冠疫苗加强针接种情况、对新冠疫苗接种的态度和信念等问题。采用多因素逻辑回归来确定影响疫苗犹豫的因素。在264名参与者中，65%的人对新冠疫苗加强针接种表现出犹豫。女性、中年、教育程度较低、被诊断患有抑郁症、担心疫苗副作用、对疫苗效力缺乏信心以及依赖媒体信息与疫苗犹豫呈正相关。相反，患有心血管疾病或2型糖尿病的人、通常遵循治疗医生建议的人以及之前接种过流感疫苗或接种过超过三剂新冠疫苗的人与定期接种新冠疫苗呈正相关。因此，我们的研究结果有助于制定可能减少哮喘或COPD患者定期接种疫苗犹豫的策略。
