Bonanni Paolo, Maio Michele, Beretta Giordano D, Icardi Giancarlo, Rossi Alessandro, Cinieri Saverio
Department of Health Sciences, University of Florence, Viale G.B. Morgagni 48, 50134 Florence, Italy.
Medical Oncology, Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.
Vaccines (Basel). 2024 Apr 16;12(4):420. doi: 10.3390/vaccines12040420.
Patients with cancer can be immunocompromised because of their disease and/or due to anticancer therapy. In this population, severe influenza virus infections are associated with an elevated risk of morbidity and mortality. Influenza vaccination is therefore highly recommended in cancer patients, including those receiving anticancer therapy. However, vaccination coverage remains far below the recommended target for vulnerable subjects. Six specialists in oncology, hematology, immunology, and public health/vaccinology convened with the objective of developing strategies, based on evidence and clinical experience, for improving influenza vaccination coverage in cancer patients. This viewpoint provides an overview of current influenza vaccination recommendations in cancer patients, discusses barriers to vaccination coverage, and presents strategies for overcoming said barriers. New immunization issues raised by the COVID-19 pandemic are also addressed. Future directions include improving public education on influenza vaccination, providing the media with accurate information, improving knowledge among healthcare professionals, improving access to vaccines for cancer patients, co-administration of the influenza and COVID-19 vaccines, increased collaboration between oncologists and other health professionals, increased accessibility of digital vaccination registries to specialists, shared information platforms, and promoting immunization campaigns by healthcare systems with the support of scientific societies.
癌症患者可能由于其疾病本身和/或抗癌治疗而免疫功能低下。在这一人群中,严重的流感病毒感染与发病和死亡风险升高相关。因此,强烈建议癌症患者接种流感疫苗,包括正在接受抗癌治疗的患者。然而,疫苗接种覆盖率仍远低于针对易感人群的推荐目标。六位肿瘤学、血液学、免疫学以及公共卫生/疫苗学领域的专家齐聚一堂,目的是根据证据和临床经验制定策略,以提高癌症患者的流感疫苗接种覆盖率。本观点概述了当前针对癌症患者的流感疫苗接种建议,讨论了疫苗接种覆盖率的障碍,并提出了克服这些障碍的策略。还探讨了COVID-19大流行引发的新的免疫问题。未来的方向包括加强关于流感疫苗接种的公众教育,向媒体提供准确信息,提高医护人员的知识水平,改善癌症患者获取疫苗的途径,同时接种流感疫苗和COVID-19疫苗,肿瘤学家与其他健康专业人员之间加强合作,提高专科医生对数字疫苗接种登记系统的可及性,建立共享信息平台,以及在科学协会的支持下,推动医疗系统开展免疫接种活动。