Chan Tatjana, Ginders Julia, Kuhlmeier Evelyn, Meli Marina L, Bönzli Eva, Meili Theres, Hüttl Julia, Hatt Jean-Michel, Hindenlang Clerc Karin, Kipar Anja, Wyss Fabia, Wenker Christian, Ryser-Degiorgis Marie-Pierre, Valenzuela Agüí Cecilia, Urban Christian, Beisel Christian, Stadler Tanja, Hofmann-Lehmann Regina
Clinical Laboratory, Department of Clinical Diagnostics and Services, and Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland.
Clinic for Zoo Animals, Exotic Pets and Wildlife, Department of Small Animals, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland.
Viruses. 2024 Mar 28;16(4):521. doi: 10.3390/v16040521.
Many different animal species are susceptible to SARS-CoV-2, including a few Canidae (domestic dog and raccoon dog). So far, only experimental evidence is available concerning SARS-CoV-2 infections in red foxes (). This is the first report of SARS-CoV-2 RNA detection in a sample from a red fox. The RT-qPCR-positive fox was zoo-kept together with another fox and two bears in the Swiss Canton of Zurich. Combined material from a conjunctival and nasal swab collected for canine distemper virus diagnostics tested positive for SARS-CoV-2 RNA with Ct values of 36.9 (E gene assay) and 35.7 (RdRp gene assay). The sample was analysed for SARS-CoV-2 within a research project testing residual routine diagnostic samples from different animal species submitted between spring 2020 and December 2022 to improve knowledge on SARS-CoV-2 infections within different animal species and investigate their potential role in a One Health context. Within this project, 246 samples from 153 different animals from Swiss zoos and other wild animal species all tested SARS-CoV-2 RT-qPCR and/or serologically negative so far, except for the reported fox. The source of SARS-CoV-2 in the fox is unknown. The fox disappeared within the naturally structured enclosure, and the cadaver was not found. No further control measures were undertaken.
许多不同的动物物种都易感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2），包括一些犬科动物（家犬和貉）。到目前为止，关于赤狐感染SARS-CoV-2只有实验证据（）。这是首次在赤狐样本中检测到SARS-CoV-2 RNA的报告。这只经逆转录定量聚合酶链反应（RT-qPCR）检测呈阳性的狐狸与另一只狐狸以及两只熊一起饲养在瑞士苏黎世州的一家动物园里。为犬瘟热病毒诊断采集的结膜和鼻拭子混合样本经检测，SARS-CoV-2 RNA呈阳性，E基因检测法的Ct值为36.9，RNA依赖性RNA聚合酶（RdRp）基因检测法的Ct值为35.7。该样本是在一个研究项目中进行SARS-CoV-2分析的，该项目检测了2020年春季至2022年12月期间提交的来自不同动物物种的残留常规诊断样本，以增进对不同动物物种中SARS-CoV-2感染的了解，并在“同一个健康”背景下调查它们的潜在作用。在这个项目中，来自瑞士动物园的153种不同动物的246个样本以及其他野生动物物种的样本，到目前为止经SARS-CoV-2 RT-qPCR检测和/或血清学检测均为阴性，只有报告的那只狐狸呈阳性。狐狸体内SARS-CoV-2的来源不明。这只狐狸在自然结构的围栏内失踪，尸体未被找到。没有采取进一步的防控措施。
