Ruiz-Yu Bernalyn, Le Thanh P, Weintraub Marc J, Zinberg Jamie, Addington Jean, O'Brien Mary P, Walsh Barbara C, Friedman-Yakoobian Michelle, Auther Andrea, Domingues Isabel, Cannon Tyrone D, Miklowitz David J, Bearden Carrie E
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California, USA.
Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
Early Interv Psychiatry. 2024 Dec;18(12):981-990. doi: 10.1111/eip.13541. Epub 2024 Apr 27.
There is limited research on the effects of sociodemographic and socioeconomic factors on treatment outcomes in youth at clinical high risk for psychosis (CHRp). This study examined sociodemographic factors that may affect functional outcomes within this population. Specifically, we investigated the influence of race/ethnicity (dichotomized as non-Hispanic whites [NHW] vs. people of colour [POC]), socioeconomic status (SES; operationalized as parental years of education), and their interaction on change in psychosocial functioning and symptoms over 6 months in a randomized trial of family-focused therapy.
CHRp youth (N = 128) participated in a randomized trial of family therapy (18 sessions of family therapy vs. 3 sessions of family psychoeducation). Sixty-four participants who self-identified as POC and 64 self-identified NHW participants completed baseline and 6-month follow-up measures of positive and negative symptoms and psychosocial (global, role, and social) functioning. Multiple regression models were conducted to test the main effect of race/ethnicity on changes in positive and negative symptoms and functioning, and whether this effect was moderated by parental education.
There was a significant interaction between race/ethnicity and parental education, such that higher parental education was associated with greater improvement in global functioning in NHW participants, but there was no relationship between parental education and global functioning in POC. Additionally, higher parental education was associated with a decrease in negative symptoms in NHW participants but not in POC. There were no significant effects of race/ethnicity or parental education on positive symptoms, nor on social or role functioning.
Clinicians may consider tailoring psychosocial treatments according to the needs of diverse families who vary in sociodemographic factors such as educational attainment and race/ethnicity.
关于社会人口学和社会经济因素对临床高危精神病性青年(CHRp)治疗结果影响的研究有限。本研究考察了可能影响该人群功能结局的社会人口学因素。具体而言,我们在一项以家庭为中心治疗的随机试验中,研究了种族/民族(分为非西班牙裔白人[NHW]与有色人种[POC])、社会经济地位(SES;以父母受教育年限衡量)及其相互作用对6个月内心理社会功能和症状变化的影响。
CHRp青年(N = 128)参与了家庭治疗的随机试验(18次家庭治疗与3次家庭心理教育)。64名自我认定为POC的参与者和64名自我认定为NHW的参与者完成了阳性和阴性症状以及心理社会(总体、角色和社会)功能的基线和6个月随访测量。进行多元回归模型以检验种族/民族对阳性和阴性症状及功能变化的主要影响,以及这种影响是否受父母教育程度的调节。
种族/民族与父母教育程度之间存在显著交互作用,即较高的父母教育程度与NHW参与者总体功能的更大改善相关,但POC参与者的父母教育程度与总体功能之间无关联。此外,较高的父母教育程度与NHW参与者阴性症状的减少相关,但与POC参与者无关。种族/民族或父母教育程度对阳性症状、社会或角色功能均无显著影响。
临床医生可考虑根据社会人口学因素(如教育程度和种族/民族)不同的多样化家庭的需求,调整心理社会治疗方法。