Mittal Vishnu, Barak Ashima, Sharma Anjali, Singhal Abhinav
Department of Pharmaceutics, Guru Gobind Singh College of Pharmacy, Yamunanagar, (135001), Haryana, India.
Curr Rheumatol Rev. 2024 Apr 25. doi: 10.2174/0115733971294467240326074155.
Rheumatoid Arthritis (RA) is an inflammatory disease that causes severe joint destruction and persistent inflammation. This review aims to evaluate the efficacy, safety, and mechanisms of action of various herbal interventions in managing RA, providing valuable insights for patients and healthcare practitioners. To investigate the anti-inflammatory and antioxidant properties of selected herbal interventions, including turmeric, ginger, Boswellia serrata (frankincense), green tea, and Ashwagandha, to assess their potential as complementary treatments for RA, a comprehensive analysis is performed on the anti-inflammatory mechanisms and antioxidant effects of selected herbs. Emphasis is placed on the modulation of key inflammatory pathways and their ability to counteract oxidative stress, which are crucial factors in RA progression. Safety profiles and potential adverse effects of herbal remedies are also scrutinized. The review reveals promising evidence supporting the efficacy of turmeric and ginger in alleviating RA symptoms by modulating inflammatory pathways. Additionally, Boswellia serrata shows potential as an adjunct therapy for joint health and inflammation. The antioxidant-rich properties of green tea and Ashwagandha are highlighted, suggesting their role in counteracting oxidative stress associated with RA. In conclusion, while herbal remedies like turmeric, ginger, Boswellia serrata, green tea, and Ashwagandha offer potential complementary treatments for RA, their safety profiles and adverse effects warrant careful consideration. Rigorous clinical trials are needed to confirm their efficacy and safety, highlighting the necessity for further research in this area. These findings are crucial for patients and healthcare providers in making informed decisions about incorporating herbal interventions into RA treatment strategies.
类风湿关节炎（RA）是一种炎症性疾病，会导致严重的关节破坏和持续性炎症。本综述旨在评估各种草药干预措施在治疗RA方面的疗效、安全性和作用机制，为患者和医疗从业者提供有价值的见解。为了研究所选草药干预措施（包括姜黄、生姜、乳香、绿茶和南非醉茄）的抗炎和抗氧化特性，以评估它们作为RA辅助治疗的潜力，对所选草药的抗炎机制和抗氧化作用进行了全面分析。重点关注关键炎症途径的调节及其对抗氧化应激的能力，这些是RA进展中的关键因素。还对草药疗法的安全性概况和潜在不良反应进行了审查。该综述揭示了有前景的证据，支持姜黄和生姜通过调节炎症途径缓解RA症状的疗效。此外，乳香显示出作为关节健康和炎症辅助治疗的潜力。突出了绿茶和南非醉茄富含抗氧化剂的特性，表明它们在对抗与RA相关的氧化应激中的作用。总之，虽然姜黄、生姜、乳香、绿茶和南非醉茄等草药疗法为RA提供了潜在的辅助治疗方法，但它们的安全性概况和不良反应值得仔细考虑。需要进行严格的临床试验来证实它们的疗效和安全性，突出了该领域进一步研究的必要性。这些发现对于患者和医疗服务提供者在将草药干预措施纳入RA治疗策略时做出明智决策至关重要。
