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通过草药疗法治疗类风湿性关节炎的全景式综述。

A Panoramic Review on the Management of Rheumatoid Arthritis through Herbalism.

作者信息

Chaudhary Shikha, Sharma Shaweta, Fuloria Shivkanya

机构信息

Department of Pharmacy, School of Medical & Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India.

Faculty of Pharmacy, AIMST University, Semeling Campus, Bedong, Kedah Aman, Malaysia.

出版信息

Curr Rheumatol Rev. 2025;21(1):4-24. doi: 10.2174/0115733971279100240328063232.

Abstract

Arthritis is a chronic inflammatory condition that affects millions of individuals worldwide. The conventional treatment options for arthritis often come with limitations and potential side effects, leading to increased interest in herbal plants as alternative therapies. This article provides a comprehensive overview of the use of herbal plants in arthritis treatment, focusing on their traditional remedies, active components, mechanisms of action, and pharmaceutical approaches for enhancing their delivery. Various herbal plants, including turmeric, ginger, Boswellia, and willow bark, have shown anti-inflammatory and analgesic properties, making them valuable options for managing arthritis symptoms. The active components of these herbal plants, such as curcumin, gingerols, and boswellic acids, contribute to their therapeutic effects. To enhance the delivery of herbal medicines, pharmaceutical approaches like nanoparticle-based drug delivery systems, liposomes, polymeric nanoparticles, nanoemulsions, microneedles, and inhalation systems have been explored. These approaches aim to improve bioavailability, targeted delivery, and controlled release of herbal compounds. Safety considerations, including potential interactions with medications and the risk of allergic reactions, are also discussed. Future perspectives for this field involve conducting well-designed clinical studies, enhancing standardization and quality control measures, exploring novel drug delivery systems, and fostering collaborations between traditional medicine practitioners and healthcare professionals. Continued research and development in these areas will help unlock the full potential of herbal plants in arthritis treatment, offering personalized and effective care for affected individuals.

摘要

关节炎是一种慢性炎症性疾病,影响着全球数百万人。关节炎的传统治疗方法往往存在局限性和潜在的副作用,这使得人们对草药作为替代疗法的兴趣日益增加。本文全面概述了草药在关节炎治疗中的应用,重点介绍了它们的传统疗法、活性成分、作用机制以及增强其递送效果的制药方法。包括姜黄、生姜、乳香和柳树皮在内的各种草药已显示出抗炎和止痛特性,使其成为管理关节炎症状的宝贵选择。这些草药的活性成分,如姜黄素、姜辣素和乳香酸,有助于发挥其治疗作用。为了提高草药的递送效果,人们探索了基于纳米颗粒的药物递送系统、脂质体、聚合物纳米颗粒、纳米乳液、微针和吸入系统等制药方法。这些方法旨在提高草药化合物的生物利用度、靶向递送和控释效果。还讨论了安全方面的考虑因素,包括与药物的潜在相互作用和过敏反应风险。该领域的未来展望包括开展精心设计的临床研究、加强标准化和质量控制措施、探索新型药物递送系统,以及促进传统医学从业者与医疗保健专业人员之间的合作。在这些领域持续进行研究和开发将有助于释放草药在关节炎治疗中的全部潜力,为受影响的个体提供个性化且有效的护理。

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