Mohanty Satyajit, Pattnaik Ashok
Division of Pharmacology, Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835 215, India.
Comb Chem High Throughput Screen. 2025;28(9):1459-1490. doi: 10.2174/0113862073285538240417051928.
Medicinal plants play a crucial role in traditional medicine, where they are extensively employed by traditional physicians for treating a wide array of ailments. (Linn), commonly known as the Wood apple and belonging to the Rutaceae family, is widely cultivated in countries, such as Pakistan, India, and Sri Lanka. The various parts of , including its roots, leaves, fruits, stem, and even the whole plant, have been traditionally used in the treatment of numerous conditions, such as constipation, diarrhea, dysentery, skin diseases, asthma, astringent, diabetes, jaundice, and dyspepsia and act as diuretic agents, cardiotonic, cardiac stimulant, and hepato-protectant. Extensive research has revealed that a rich chemical composition, including quinones, lignans, flavonoids, sterols, coumarins, alkaloids, triterpenoids, phenolic acids, and volatile oils, present in its stem, leaves, fruits, stem bark, and roots. These chemical constituents contribute to its diverse therapeutic properties. In recent years, numerous studies have explored the ethanopharmacological properties of extracts, highlighting their anticancer, antidiabetic, anti-diarrheal, antimicrobial, antiulcer, wound healing, antioxidant, hepatoprotective, antibacterial, antifungal, larvicidal, neuroprotective, antispermatogenic, antihistaminic, diuretic, and adsorbent activities. This comprehensive review focuses on the traditional uses, biological activities, and phytoconstituents isolated from different parts of Limonia acidissima Linn. The gathered information provides valuable insights into the therapeutic potential of this plant, serving as a foundation for further research and the development of novel pharmaceuticals. The integration of traditional knowledge with scientific evidence enhances the understanding of the medicinal properties of , fostering its utilization in modern medicine and healthcare systems.
药用植物在传统医学中发挥着至关重要的作用，传统医生广泛使用它们来治疗各种各样的疾病。酸橙（Limonia acidissima Linn.），俗称木苹果，属于芸香科，在巴基斯坦、印度和斯里兰卡等国家广泛种植。酸橙的各个部位，包括其根、叶、果实、茎，甚至整株植物，传统上都被用于治疗多种病症，如便秘、腹泻、痢疾、皮肤病、哮喘、收敛剂、糖尿病、黄疸和消化不良，并可作为利尿剂、强心剂、心脏兴奋剂和肝脏保护剂。广泛的研究表明，酸橙的茎、叶、果实、茎皮和根中含有丰富的化学成分，包括醌类、木脂素、黄酮类、甾醇、香豆素、生物碱、三萜类、酚酸和挥发油。这些化学成分赋予了它多样的治疗特性。近年来，许多研究探索了酸橙提取物的民族药理学特性，突出了它们的抗癌、抗糖尿病、止泻、抗菌、抗溃疡、伤口愈合、抗氧化、肝脏保护、抗菌、抗真菌、杀幼虫、神经保护、抗精子生成、抗组胺、利尿和吸附活性。这篇综述聚焦于酸橙不同部位的传统用途、生物活性和分离出的植物成分。收集到的信息为这种植物的治疗潜力提供了有价值的见解，为进一步研究和开发新型药物奠定了基础。将传统知识与科学证据相结合，增进了对酸橙药用特性的理解，促进了其在现代医学和医疗保健系统中的应用。
