Shen Jianing, Ma Zhengtai, Xu Jiaqi, Xue Tianhao, Lv Xiaoqing, Zhu Guixian, Huang Beiju
School of Instrument Science and Optoelectronic Engineering, Beijing Information Science and Technology University, Beijing 100192, China.
Key Laboratory of Optoelectronic Materials and Devices, Chinese Academy of Sciences, Beijing 100083, China.
ACS Appl Mater Interfaces. 2024 Apr 27. doi: 10.1021/acsami.3c19396.
Exosomes are becoming more widely acknowledged as significant circulating indicators for the prognosis and diagnosis of cancer. Circulating exosomes are essential to the development and spread of cancer, according to a growing body of research. Using existing technology, characterizing exosomes is quite difficult. Therefore, a direct, sensitive, and targeted approach to exosome detection will aid in illness diagnosis and prognosis. The review discusses the new strategies for exosome isolation and detection technologies from microfluidic chips to nanoplasmonic biosensors, analyzing the advantages and limitations of these new technologies. This review serves researchers to better understand exosome isolation and detection methods and to help develop better exosome isolating and detecting devices for clinical applications.
外泌体作为癌症预后和诊断的重要循环指标,正越来越受到广泛认可。越来越多的研究表明,循环外泌体对癌症的发展和扩散至关重要。利用现有技术,对外泌体进行表征相当困难。因此,一种直接、灵敏且有针对性的外泌体检测方法将有助于疾病的诊断和预后。这篇综述讨论了从微流控芯片到纳米等离子体生物传感器的外泌体分离和检测技术的新策略,分析了这些新技术的优缺点。这篇综述有助于研究人员更好地理解外泌体分离和检测方法,并有助于开发出更好的用于临床应用的外泌体分离和检测设备。