胃穿孔活检：它过时了吗？
Gastric perforation biopsy: is it obsolete?
作者信息
Steyn Petre Francois, Karusseit Otto
机构信息
Department of Surgery, University of Pretoria Medical School, Pretoria, South Africa.
出版信息
Langenbecks Arch Surg. 2024 Apr 27;409(1):139. doi: 10.1007/s00423-024-03325-9.
PURPOSE
The aim of the study was to test the established hypothesis that biopsies of spontaneous gastric perforations should be taken to rule out cancer.
METHODS
A prospective observational study was performed. Consecutive patients with spontaneous gastric perforation were included. Biopsies of the edges of the perforation were submitted for histological evaluation. The epithelial type as well as the nature of the pathology were evaluated.
RESULTS
Sixty-eight patients were included. Eight (12%) biopsies revealed duodenal origin. Sixty (88%) biopsies revealed gastric mucosa of which 33 (48%) could be specifically typed. All biopsies revealed benign ulceration. No malignancies were detected in these biopsies or on subsequent gastroscopic follow up.
CONCLUSION
This study suggests that routine intraoperative biopsy of gastric perforation may be questioned. Biopsy is probably better performed endoscopically after recovery.
目的
本研究旨在验证已确立的假设，即应对自发性胃穿孔进行活检以排除癌症。
方法
进行了一项前瞻性观察性研究。纳入连续的自发性胃穿孔患者。将穿孔边缘的活检组织送检进行组织学评估。评估上皮类型以及病理性质。
结果
纳入68例患者。8例（12%）活检显示为十二指肠起源。60例（88%）活检显示为胃黏膜，其中33例（48%）可明确分型。所有活检均显示为良性溃疡。这些活检组织及随后的胃镜随访中均未检测到恶性肿瘤。
结论
本研究表明，胃穿孔的常规术中活检可能值得质疑。活检可能在恢复后通过内镜检查进行更好。
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