Northeast Asia Research Institute of Traditional Chinese Medicine, Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Ministry of Education, Jilin Provincial Key Laboratory of Bio-Macromolecules of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin 130117, China.
Research Center of Traditional Chinese Medicine, College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin 130021, China.
Int J Biol Macromol. 2024 Jun;269(Pt 1):131872. doi: 10.1016/j.ijbiomac.2024.131872. Epub 2024 Apr 25.
The increasing incidence of obesity has led to widespread attention in the exploration of natural ingredients. Ginseng polysaccharides (PGP), the main components from Panax ginseng, have been reported potential effect to attenuate obesity and regulate lipid metabolism. In this study, we found that PGP inhibited the high-fat diet (HFD)-induced weight gain, fat ratio and fat tissue weight after 8-week administration. Serum and liver lipid analysis showed that PGP decreased the levels of triglyceride and total cholesterol, which was mediated by the inhibition of key genes for fatty acid and cholesterol metabolisms. Metabolomics studies showed that the inhibitory effect of PGP on liver lipid accumulation was significantly correlated with its regulation of citric acid cycle and lysine degradation. PGP regulated the expression of genes related to lysine degradation in both liver tissue and hepatocytes. In addition, PGP reshaped the composition of fecal microbiota at the genus and species levels in obese mice. Spearman's correlation analysis demonstrated that Staphylococcus sciuri, Staphylococcus lentus, and Pseudoflavonifractor sp. An85 may be the potential targets that PGP maintains the abundance of l-lysine against obesity. It concluded that PGP can attenuate obesity and liver lipid accumulation by regulating fecal microbiota and hepatic lysine degradation.
肥胖症发病率的不断上升导致人们广泛关注对天然成分的探索。人参多糖（PGP）是人参的主要成分之一，据报道其具有减轻肥胖和调节脂质代谢的潜力。在这项研究中，我们发现 PGP 在 8 周的给药后可抑制高脂肪饮食（HFD）引起的体重增加、脂肪比和脂肪组织重量。血清和肝脏脂质分析表明，PGP 降低了甘油三酯和总胆固醇水平，这是通过抑制脂肪酸和胆固醇代谢的关键基因来介导的。代谢组学研究表明，PGP 对肝脏脂质积累的抑制作用与其对柠檬酸循环和赖氨酸降解的调节显著相关。PGP 调节了肝脏组织和肝细胞中与赖氨酸降解相关的基因的表达。此外，PGP 在肥胖小鼠中重塑了粪便微生物群落的组成在属和种水平上。Spearman 相关性分析表明，松鼠葡萄球菌、迟缓葡萄球菌和拟短状杆菌 An85 可能是 PGP 维持赖氨酸丰度以对抗肥胖的潜在靶点。综上所述，PGP 可通过调节粪便微生物群和肝脏赖氨酸降解来减轻肥胖和肝脏脂质积累。
