Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Anticancer Res. 2024 May;44(5):2009-2019. doi: 10.21873/anticanres.17004.
BACKGROUND/AIM: Although serum squamous cell carcinoma (SCC) antigen values are known to be useful in predicting the prognosis of cervical SCC, they have only been examined in a cursory manner. This study aimed to meticulously investigate the clinical significance of serum SCC antigen levels in patients with locally advanced cervical squamous cell carcinoma (LACSC).
The study included patients who were diagnosed with local stage (T-stage) 1b3/2/3 LACSC and underwent initial treatment at our institute between January 2006 and December 2016 (T-1b3: n=30; T-2: n=75; T-3: n=34). The patients were divided into three groups based on pre-treatment SCC values, and differences in clinical background, laboratory and pathology findings, and prognosis were examined.
No significant difference in the SCC distribution was observed among the T-1b3/2/3 cases with elevated SCC levels. In stages T-1b3, T-2, and T-3, most recurrences in the SCC-High group were distant (T-1b3: three out of five recurrences; T-2: six out of seven recurrences; T-3: four out of eight recurrences), while most recurrences in the SCC-Low group were pelvic (T-1b3: two out of three recurrences; T-2: eight out of eight recurrences; T-3: three out of three recurrences).
In LACSC, serum SCC antigen levels before treatment correlate strongly with the recurrence site. Patients with low levels should be closely monitored for local recurrence, whereas those with high levels warrant vigilance for distant recurrence.
背景/目的：虽然血清鳞状细胞癌（SCC）抗原值已被证明可用于预测宫颈 SCC 的预后，但仅进行了粗略的检查。本研究旨在详细研究局部晚期宫颈鳞状细胞癌（LACSC）患者血清 SCC 抗原水平的临床意义。
本研究纳入了 2006 年 1 月至 2016 年 12 月期间在我院初诊为局部分期（T 分期）1b3/2/3 LACSC 的患者（T-1b3：n=30；T-2：n=75；T-3：n=34）。根据治疗前 SCC 值将患者分为三组，比较三组患者的临床背景、实验室和病理学检查结果及预后。
T-1b3/2/3 期 SCC 值升高患者的 SCC 分布无明显差异。在 T-1b3、T-2 和 T-3 期，SCC-高组的大多数复发均为远处转移（T-1b3：5 例复发中有 3 例；T-2：7 例复发中有 6 例；T-3：8 例复发中有 4 例），而 SCC-低组的大多数复发为盆腔（T-1b3：3 例复发中有 2 例；T-2：8 例复发中有 8 例；T-3：3 例复发中有 3 例）。
在 LACSC 中，治疗前血清 SCC 抗原水平与复发部位密切相关。水平较低的患者应密切监测局部复发，而水平较高的患者则需要警惕远处转移。
