Department of Radiation Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, No. 420 Fuma Road, Fuzhou, 350000, Fujian, China.
Radiat Oncol. 2022 Jan 10;17(1):6. doi: 10.1186/s13014-021-01978-0.
To investigate the prognostic relevance of specific measurement parameters such as tumor diameter, tumor volume, tumor volume reduction rate (TVRR), and changes in the squamous cell carcinoma antigen (SCC-Ag) level in patients with locally-advanced cervical cancer (LACC) undergoing concurrent radiotherapy and chemotherapy.
This was a retrospective study of 203 patients with stage IIA-IVA cervical squamous cell carcinoma who were newly diagnosed at our hospital between January 2011 and March 2015. Clinical data and pre-and post-treatment imaging information were collected and each parameter was calculated using 3DSlicer software. The pre/post-treatment tumor diameter (TD), tumor volume (TV), SCC-Ag (SCC), and TVRR, SCC-Ag reduction rate (SCCRR) were analyzed and their prognostic relevance evaluated.
The median follow-up was 69 months. The 5-year overall survival (OS) and disease progression-free survival (PFS) rates were 69.5% and 64.5%, respectively. On univariate analysis, TD, TV, TVRR, SCC and SCCRR showed significant association with OS and PFS (P < 0.05). On multivariate analysis, TD [Hazard ratio (HR) = 0.373, P = 0.028], TD (HR = 0.376, P = 0.003) and SCC (HR = 0.374, P = 0.001) were independent predictors of OS. TVRR (HR = 2.998, P < 0.001), SCC (HR = 0.563, P = 0.041), and SCC (HR = 0.253, P < 0.001) were independent predictors of PFS. Tumor measurement parameters showed a positive correlation with SCC-Ag (P < 0.05).
TD, TV, TVRR, SCC, and SCCRR were prognostic factors in LACC. TD and SCC showed the most significant prognostic value. TVRR and SCC were closely related to disease progression. Further studies should investigate the correlation between measurement parameters of tumor and SCC-Ag.
探讨特定测量参数在同步放化疗的局部晚期宫颈癌（LACC）患者中的预后相关性，这些参数包括肿瘤直径、肿瘤体积、肿瘤体积减少率（TVRR）和鳞状细胞癌抗原（SCC-Ag）水平的变化。
这是一项回顾性研究，共纳入 203 例 2011 年 1 月至 2015 年 3 月期间在我院新诊断为宫颈鳞状细胞癌的 IIA-IVA 期患者。收集临床数据和治疗前后的影像学信息，并使用 3DSlicer 软件计算每个参数。分析治疗前后肿瘤直径（TD）、肿瘤体积（TV）、SCC-Ag（SCC）、TVRR 和 SCC-Ag 减少率（SCCRR），并评估其预后相关性。
中位随访时间为 69 个月。5 年总生存率（OS）和无疾病进展生存率（PFS）分别为 69.5%和 64.5%。单因素分析显示，TD、TV、TVRR、SCC 和 SCCRR 与 OS 和 PFS 显著相关（P<0.05）。多因素分析显示，TD[风险比（HR）=0.373，P=0.028]、TD（HR=0.376，P=0.003）和 SCC（HR=0.374，P=0.001）是 OS 的独立预测因素。TVRR（HR=2.998，P<0.001）、SCC（HR=0.563，P=0.041）和 SCC（HR=0.253，P<0.001）是 PFS 的独立预测因素。肿瘤测量参数与 SCC-Ag 呈正相关（P<0.05）。
TD、TV、TVRR、SCC 和 SCCRR 是 LACC 的预后因素。TD 和 SCC 具有最显著的预后价值。TVRR 和 SCC 与疾病进展密切相关。应进一步研究肿瘤测量参数与 SCC-Ag 的相关性。
