在普通狨猴（Callithrix jacchus）的前列腺中发现 PSMA。
Discovery of PSMA in the prostate of the common marmoset (Callithrix jacchus).
机构信息
Johns Hopkins Drug Discovery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
出版信息
Prostate. 2024 Aug;84(11):1086-1088. doi: 10.1002/pros.24722. Epub 2024 Apr 28.
BACKGROUND
Prostate-specific membrane antigen (PSMA) is a biomarker and therapeutic target of high relevance in prostate cancer. Although upregulated PSMA expression is a well-documented feature of prostatic neoplasia in both humans and canids, to date humans are the only species known to express PSMA basally in the prostate. Thus, traditional laboratory animal species have limited utility for studying PSMA biology in the prostate or for predicting efficacy or toxicity of PSMA-targeted agents.
METHODS
PSMA expression in human, macaque, and marmoset prostates was determined by immunohistochemistry, employing an antibody with validated cross-species reactivity in a PSMA-positive control tissue; kidney.
RESULTS
We newly discover that the common marmoset endogenously expresses PSMA in non-diseased prostate, similar to humans, and thus may be a valuable preclinical model for researchers studying PSMA.
背景
前列腺特异性膜抗原（PSMA）是前列腺癌中具有高度相关性的生物标志物和治疗靶点。虽然 PSMA 的表达上调是人及犬科动物前列腺肿瘤的一个有充分文献记载的特征，但迄今为止，已知只有人类在前列腺中基础表达 PSMA。因此，传统的实验动物物种在研究前列腺中的 PSMA 生物学或预测 PSMA 靶向药物的疗效或毒性方面的应用有限。
方法
用人、猕猴和狨猴的前列腺组织通过免疫组织化学方法，用在 PSMA 阳性对照组织（肾脏）中具有经过验证的交叉物种反应性的抗体来确定 PSMA 的表达。
结果
我们新发现普通狨猴在非病变前列腺中内源性表达 PSMA，与人类相似，因此可能是研究 PSMA 的研究人员的有价值的临床前模型。
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