Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Medical Scientist Training Program, School of Medicine, University of California, Irvine, Irvine, California, USA.
J Invest Dermatol. 2024 Jun;144(6):1208-1216. doi: 10.1016/j.jid.2023.11.016. Epub 2024 Apr 26.
IL-17 is widely recognized for its roles in host defense and inflammatory disorders. However, it has become clear that IL-17 is also an essential regulator of barrier tissue physiology. Steady-state microbe sensing at the skin surface induces low-level IL-17 expression that enhances epithelial integrity and resists pathogens without causing overt inflammation. Recent reports describe novel protective roles for IL-17 in wound healing and counteracting physiologic stress; however, chronic amplification of these beneficial responses contributes to skin pathologies as diverse as fibrosis, cancer, and autoinflammation. In this paper, we discuss the context-specific roles of IL-17 in skin health and disease and therapeutic opportunities.
IL-17 在宿主防御和炎症性疾病中具有广泛的作用。然而，现在已经很清楚，IL-17 也是屏障组织生理学的重要调节剂。在皮肤表面进行稳态微生物感应会诱导低水平的 IL-17 表达，从而增强上皮完整性并抵抗病原体，而不会引起明显的炎症。最近的报告描述了 IL-17 在伤口愈合和对抗生理应激方面的新的保护作用；然而，这些有益反应的慢性放大导致了多种皮肤病理，如纤维化、癌症和自身炎症。在本文中，我们讨论了 IL-17 在皮肤健康和疾病以及治疗机会中的特定作用。
