髓系细胞表面可溶性触发受体（sTREM-1）和干扰素诱导蛋白-10（IP-10）对儿童重症支原体肺炎的诊断价值

Diagnostic values of soluble triggering receptor expressed on myeloid cells (sTREM-1) and interferon-inducible protein-10 (IP-10) for severe mycoplasma pneumoniae pneumonia in children.

作者信息

Xu Chang, Luo Li-Yan, Wu Bi-Chen, Ding Niu, Jin Shi-Jie, Huang Jian-Bao, Chen Yan-Ping

机构信息

Department of Respiratory, Hunan Children's Hospital, Changsha, China.

出版信息

Clinics (Sao Paulo). 2024 Apr 27;79:100361. doi: 10.1016/j.clinsp.2024.100361. eCollection 2024.

DOI:10.1016/j.clinsp.2024.100361

PMID:38678873

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11066589/

Abstract

OBJECTIVE

Early diagnosis of Severity Mycoplasma Pneumoniae Pneumonia (SMPP) has been a worldwide concern in clinical practice. Two cytokines, soluble Triggering Receptor Expressed on Myeloid cells (sTREM-1) and Interferon-Inducible Protein-10 (IP-10), were proved to be implicated in bacterial infection diseases. However, the diagnostic value of sTREM-1 and IP-10 in MPP was poorly known. This study aimed to investigate the diagnostic value of sTREM-1 and IP-10 for SMPP.

METHODS

In this prospective study, the authors enrolled 44 children with MPP, along with their clinical information. Blood samples were collected, and cytokine levels of sTREM-1 and IP-10 were detected with ELISA assay.

RESULTS

Serum levels of sTREM-1 and IP-10 were positively correlated with the severity of MPP. In addition, sTREM-1 and IP-10 have significant potential in the diagnosis of SMPP with an Area Under Curve (AUC) of 0.8564 (p-value = 0.0001, 95% CI 0.7461 to 0.9668) and 0.8086 (p-value = 0.0002, 95% CI 0.6918 to 0.9254) respectively. Notably, the combined diagnostic value of sTREM-1 and IP-10 is up to 0.911 in children with SMPP (p-value < 0.001, 95% CI 0.830 to 0.993).

CONCLUSIONS

Serum cytokine levels of sTREM-1 and IP-10 have a great potential diagnostic value in children with SMPP.

摘要

目的

重症支原体肺炎（SMPP）的早期诊断一直是临床实践中全球关注的问题。两种细胞因子，即髓系细胞表面表达的可溶性触发受体（sTREM-1）和干扰素诱导蛋白10（IP-10），已被证明与细菌感染性疾病有关。然而，sTREM-1和IP-10在支原体肺炎（MPP）中的诊断价值鲜为人知。本研究旨在探讨sTREM-1和IP-10对SMPP的诊断价值。

方法

在这项前瞻性研究中，作者纳入了44例MPP患儿及其临床信息。采集血样，采用酶联免疫吸附测定法检测sTREM-1和IP-10的细胞因子水平。

结果

sTREM-1和IP-10的血清水平与MPP的严重程度呈正相关。此外，sTREM-1和IP-10在SMPP诊断中具有显著潜力，曲线下面积（AUC）分别为0.8564（p值 = 0.0001，95%置信区间0.7461至0.9668）和0.8086（p值 = 0.0002，95%置信区间0.6918至0.9254）。值得注意的是，sTREM-1和IP-10联合诊断价值在SMPP患儿中高达0.911（p值 < 0.001，95%置信区间0.830至0.993）。