Bynum L J, Wilson J E
Am J Med. 1979 Oct;67(4):553-6. doi: 10.1016/0002-9343(79)90224-9.
The efficacy of a six-month course of low-dose heparin therapy was compared to a conventional warfarin regimen by a prospective, controlled trial in 48 patients with pulmonary embolism or deep venous thrombosis of the legs. All subjects had complicated medical illnesses and a high risk of recurrent thromboembolism. Bleeding complications were virtually negligible during heparin therapy and occurred significantly more frequently in patients receiving warfarin. Heparin was as effective as warfarin in the prevention of recurrent thromboembolism. Patient compliance with the two treatment regimens was comparable. Self-administered, low-dose heparin therapy is a useful alternative to warfarin in the long-term management of complicated thromboembolic disorders.
通过一项前瞻性对照试验，对48例患有肺栓塞或下肢深静脉血栓形成的患者进行了为期6个月的低剂量肝素治疗与传统华法林治疗方案的疗效比较。所有受试者均患有复杂的内科疾病，且复发性血栓栓塞风险高。肝素治疗期间出血并发症几乎可以忽略不计，而接受华法林治疗的患者出血并发症发生频率明显更高。肝素在预防复发性血栓栓塞方面与华法林效果相当。患者对两种治疗方案的依从性相当。自我给药的低剂量肝素治疗是华法林在复杂血栓栓塞性疾病长期管理中的一种有用替代方法。
